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Clinical Outcome and Histological Findings After Induced Leakage of PMMA Loaded With Methotrexate and Cisplatin During Vertebroplasty: Experimental Model in Pigs

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dc.contributor.authorSilva, Alvaro
dc.contributor.authorLlombart-Blanco, Rafael
dc.contributor.authorGallegos Angulo, Marcela
dc.contributor.authorVillas Tomé, Carlos
dc.contributor.authorOlmos-García, Matías Alfonso
dc.date.accessioned2024-06-04T17:35:42Z
dc.date.available2024-06-04T17:35:42Z
dc.date.issued2023
dc.description.abstractStudy Design: Animal experimental model. Objective: Tostudy the clinical behavior and histological changes in the spinal cord, nerve roots and perivertebral muscles of the spine after induced leakage of polymethylmethacrylate (PMMA) loaded with antiblastic drugs during vertebroplasty in an animal model of pigs. Methods: We performed vertebroplasty on 25 pigs. The animals were divided into 3 groups: vertebroplasty with PMMA alone (control group), vertebroplasty with PMMA loaded with methotrexate (MTX) and vertebroplasty with PMMA loaded with cis platin (CYS). At 2 vertebral levels, epidural and prevertebral, massive cement leaks were induced. Animals were evaluated daily. Two weeks later, the pigs were sacrificed, and the tissues that came in contact with the cement were analyzed. Results: The clinical results for each of the groups were reported. The control group had no clinical alterations. In the MTX group, 2 pigs died before 1 week due to pneumonitis. In the CYS group, 4 animals had motor impairment, and 3 of the 4 had paraplegia. The histological results were as follows: the control and MTX groups showed synovial metaplasia, inflammatory reaction, crystal deposits, and giant cell reaction in the dura mater and muscle and all the animals in the CYS group had spinal cord and muscular necrosis. Conclusions: Massive cement leak after vertebroplasty with PMMA loaded with cisplatin is extremely toxic to the spinal cord and muscles around the spine. Therefore, its use cannot be recommended for the treatment of vertebral metastases. Using PMMA loaded with methotrexate seems to be a safe procedure, but further research is needed
dc.description.versionVersión publicada
dc.format.extent8 p.
dc.identifier.citationGlobal Spine Journal 2023, Vol. 13(1) 156–163
dc.identifier.doihttps://doi.org/10.1177/2192568221994800
dc.identifier.urihttps://hdl.handle.net/11447/9021
dc.language.isoen
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/cl/
dc.subjectVertebroplasty
dc.subjectAcrylic cement
dc.subjectCisplatin
dc.subjectMethotrexate
dc.subjectLeakage
dc.titleClinical Outcome and Histological Findings After Induced Leakage of PMMA Loaded With Methotrexate and Cisplatin During Vertebroplasty: Experimental Model in Pigs
dc.typeArticle
dcterms.accessRightsAcceso abierto
dcterms.sourceGlobal Spine Journal
dspace.entity.typePublication
relation.isAuthorOfPublicationa2b04bb7-0a8f-4c0d-9062-1f545c410c9c
relation.isAuthorOfPublication.latestForDiscoverya2b04bb7-0a8f-4c0d-9062-1f545c410c9c

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