Publication:
Circulating Arsenic is Associated with Long-Term Risk of Graft Failure in Kidney Transplant Recipients: A Prospective Cohort Study

Simple item page
dc.contributor.authorSotomayor, Camilo G.
dc.contributor.authorVodegel, Joppe J.
dc.contributor.authorGacitúa, Tomás A
dc.contributor.authorGomes-Neto, António W.
dc.contributor.authorOsté, Maryse C.J.
dc.contributor.authorPol, Robert A.
dc.contributor.authorFerreccio, Catterina
dc.contributor.authorBerger, Stefan P.
dc.contributor.authorChong Medel, Guillermo
dc.contributor.authorSlart, Riemer H.J.A.
dc.contributor.authorRodrigo, Ramón
dc.contributor.authorNavis, Gerjan J.
dc.contributor.authorTouw, Daan J.
dc.contributor.authorBakker, Stephan J.L.
dc.date.accessioned2024-06-03T21:29:25Z
dc.date.available2024-06-03T21:29:25Z
dc.date.issued2023
dc.description.abstractArsenic is toxic to many organ systems, the kidney being the most sensitive target organ. We aimed to investigate whether, in kidney transplant recipients (KTRs), the nephrotoxic exposure to arsenic could represent an overlooked hazard for graft survival. We performed a prospective cohort study of 665 KTRs with a functional graft ≥1 year, recruited in a university setting (2008‒2011), in The Netherlands. Plasma arsenic was measured by ICP-MS, and dietary intake was comprehensively assessed using a validated 177-item food-frequency questionnaire. The endpoint graft failure was defined as restart of dialysis or re-transplantation. Median arsenic concentration was 1.26 (IQR, 1.04‒2.04) µg/L. In backwards linear regression analyses we found that fish consumption (std β = 0.26; p < 0.001) was the major independent determinant of plasma arsenic. During 5 years of follow-up, 72 KTRs developed graft failure. In Cox proportional-hazards regression analyses, we found that arsenic was associated with increased risk of graft failure (HR 1.80; 95% CI 1.28–2.53; p = 0.001). This association remained materially unaltered after adjustment for donor and recipient characteristics, immunosuppressive therapy, eGFR, primary renal disease, and proteinuria. In conclusion, in KTRs, plasma arsenic is independently associated with increased risk of late graft failure.
dc.description.versionVersión publicada
dc.format.extent14 p.
dc.identifier.citationSotomayor CG, Groothof D, Vodegel JJ, Gacitúa TA, Gomes-Neto AW, Osté MCJ, Pol RA, Ferreccio C, Berger SP, Chong G, et al. Circulating Arsenic is Associated with Long-Term Risk of Graft Failure in Kidney Transplant Recipients: A Prospective Cohort Study. Journal of Clinical Medicine. 2020; 9(2):417. https://doi.org/10.3390/jcm9020417
dc.identifier.doihttps://doi.org/10.3390/jcm9020417
dc.identifier.urihttps://hdl.handle.net/11447/9005
dc.language.isoen
dc.subjectArsenic
dc.subjectDiet
dc.subjectFish consumption
dc.subjectOxidative stress
dc.subjectKidney transplantation
dc.subjectGraft failure
dc.titleCirculating Arsenic is Associated with Long-Term Risk of Graft Failure in Kidney Transplant Recipients: A Prospective Cohort Study
dc.typeArticle
dcterms.accessRightsAcceso abierto
dcterms.sourceJournal of Clinical Medicine
dspace.entity.typePublication
relation.isAuthorOfPublication831a85b1-215b-4da1-b376-4cfcd61eabec
relation.isAuthorOfPublication.latestForDiscovery831a85b1-215b-4da1-b376-4cfcd61eabec

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
jcm-09-00417-v3.pdf
Size:
599.44 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
347 B
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Artículos Medicina y Ciencias de la Salud

Implementado por OpenGeek Services