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Autoantibodies Against Proteins Previously Associated With Autoimmunity in Adult and Pediatric Patients With COVID-19 and Children With MIS-C

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dc.contributor.authorBurbelo, Peter
dc.contributor.authorCastagnoli, Riccardo
dc.contributor.authorShimizu, Chisato
dc.contributor.authorDelmonte, Ottavia
dc.contributor.authorDobbs, Kerry
dc.contributor.authorDiscepolo, Valentina
dc.contributor.authorLo Vecchio, Andrea
dc.contributor.authorGuarino, Alfredo
dc.contributor.authorLicciardi, Francesco
dc.contributor.authorRamenghi, Ugo
dc.contributor.authorRey, Emma
dc.contributor.authorVial, Cecilia
dc.contributor.authorMarseglia, Gian
dc.contributor.authorLicari, Amelia
dc.contributor.authorMontagna, Daniela
dc.contributor.authorRossi, Camillo
dc.contributor.authorMontealegre, Gina
dc.contributor.authorBarron, Karyl
dc.contributor.authorWarner, Blake
dc.contributor.authorChiorini, John
dc.contributor.authorEspinosa, Yazmin
dc.contributor.authorNoguera, Loreani
dc.contributor.authorDropulic, Lesia
dc.contributor.authorTruong, Meng
dc.contributor.authorGerstbacher, Dana
dc.contributor.authorMató, Sayonara
dc.contributor.authorKanegaye, John
dc.contributor.authorTremoulet, Adriana
dc.contributor.authorPediatric Emergency Medicine Kawasaki Group
dc.contributor.authorEisenstein, Eli
dc.contributor.authorSu, Helen
dc.contributor.authorImberti, Luisa
dc.contributor.authorPoli, Cecilia
dc.contributor.authorBurns, Jane
dc.contributor.authorNotarangelo, Luigi
dc.contributor.authorCohen, Jeffrey
dc.date.accessioned2023-04-26T19:28:42Z
dc.date.available2023-04-26T19:28:42Z
dc.date.issued2022
dc.description.abstractThe antibody profile against autoantigens previously associated with autoimmune diseases and other human proteins in patients with COVID-19 or multisystem inflammatory syndrome in children (MIS-C) remains poorly defined. Here we show that 30% of adults with COVID-19 had autoantibodies against the lung antigen KCNRG, and 34% had antibodies to the SLE-associated Smith-D3 protein. Children with COVID-19 rarely had autoantibodies; one of 59 children had GAD65 autoantibodies associated with acute onset of insulin-dependent diabetes. While autoantibodies associated with SLE/Sjögren's syndrome (Ro52, Ro60, and La) and/or autoimmune gastritis (gastric ATPase) were detected in 74% (40/54) of MIS-C patients, further analysis of these patients and of children with Kawasaki disease (KD), showed that the administration of intravenous immunoglobulin (IVIG) was largely responsible for detection of these autoantibodies in both groups of patients. Monitoring in vivo decay of the autoantibodies in MIS-C children showed that the IVIG-derived Ro52, Ro60, and La autoantibodies declined to undetectable levels by 45-60 days, but gastric ATPase autoantibodies declined more slowly requiring >100 days until undetectable. Further testing of IgG and/or IgA antibodies against a subset of potential targets identified by published autoantigen array studies of MIS-C failed to detect autoantibodies against most (16/18) of these proteins in patients with MIS-C who had not received IVIG. However, Troponin C2 and KLHL12 autoantibodies were detected in 2 of 20 and 1 of 20 patients with MIS-C, respectively. Overall, these results suggest that IVIG therapy may be a confounding factor in autoantibody measurements in MIS-C and that antibodies against antigens associated with autoimmune diseases or other human proteins are uncommon in MIS-C.
dc.description.versionVersión Publicada
dc.identifier.citationBurbelo PD, Castagnoli R, Shimizu C, Delmonte OM, Dobbs K, Discepolo V, Lo Vecchio A, Guarino A, Licciardi F, Ramenghi U, Rey-Jurado E, Vial C, Marseglia GL, Licari A, Montagna D, Rossi C, Montealegre Sanchez GA, Barron K, Warner BM, Chiorini JA, Espinosa Y, Noguera L, Dropulic L, Truong M, Gerstbacher D, Mató S, Kanegaye J, Tremoulet AH; Pediatric Emergency Medicine Kawasaki Group; Eisenstein EM, Su HC, Imberti L, Poli MC, Burns JC, Notarangelo LD, Cohen JI. Autoantibodies Against Proteins Previously Associated With Autoimmunity in Adult and Pediatric Patients With COVID-19 and Children With MIS-C. Front Immunol. 2022 Mar 11;13:841126. doi: 10.3389/fimmu.2022.841126
dc.identifier.doihttps://doi.org/10.3389/fimmu.2022.841126
dc.identifier.urihttps://repositorio.udd.cl/handle/11447/7402
dc.language.isoen
dc.subjectCOVID-19
dc.subjectIVIG
dc.subjectMIS-C multisystem inflammatory syndrome in children
dc.subjectAutoantibodies
dc.subjectAutoimmunity
dc.titleAutoantibodies Against Proteins Previously Associated With Autoimmunity in Adult and Pediatric Patients With COVID-19 and Children With MIS-C
dc.typeArticle
dcterms.accessRightsAcceso abierto
dcterms.sourceFrontiers in immunology
dspace.entity.typePublication

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