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Social exposome and brain health outcomes of dementia across Latin America

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dc.contributor.authorMigeot, Joaquin
dc.contributor.authorPina, Stefanie
dc.contributor.authorHernandez, Hernan
dc.contributor.authorGonzalez, Raul
dc.contributor.authorLegaz, Agustina
dc.contributor.authorFittipaldi, Sol
dc.contributor.authorResende, Elisa de Paula França
dc.contributor.authorDuran, Claudia
dc.contributor.authorAvila, Jose
dc.contributor.authorBehrens, Maria Isabel
dc.contributor.authorBruno, Martin
dc.contributor.authorCardona, Juan
dc.contributor.authorCustodio, Nilton
dc.contributor.authorGarcía, Adolfo
dc.contributor.authorGodoy, Maria
dc.contributor.authorHu, Kun
dc.contributor.authorLanata, Serggio
dc.contributor.authorLawlor, Brian
dc.contributor.authorLopera, Francisco
dc.contributor.authorMaito, Marcelo
dc.contributor.authorMatallana, Diana
dc.contributor.authorMiller, Bruce
dc.contributor.authorMiranda, J Jaime
dc.contributor.authorOkada, Maira
dc.contributor.authorReyes, Pablo
dc.contributor.authorSantamaria, Hernando
dc.contributor.authorSlachevsky Chonchol, Andrea
dc.contributor.authorSosa, Ana
dc.contributor.authorTakada, Leonel
dc.contributor.authorTorres, Jacqueline
dc.contributor.authorVanneste, Sven
dc.contributor.authorValcour, Victor
dc.contributor.authorWen, Olivia
dc.contributor.authorYokoyama, Jennifer
dc.contributor.authorPossin, Katherine
dc.contributor.authorIbañez, Agustin
dc.date.accessioned2026-07-20T20:23:49Z
dc.date.available2026-07-20T20:23:49Z
dc.date.issued2025
dc.description.abstractA multidimensional social exposome (MSE)-the combined lifespan measures of education, food insecurity, financial status, access to healthcare, childhood experiences, and more-may shape dementia risk and brain health over the lifespan, particularly in underserved regions like Latin America. However, the MSE effects on brain health and dementia are unknown. We evaluated 2211 individuals (controls, Alzheimer's disease, and frontotemporal lobar degeneration) from a non-representative sample across six Latin American countries. Adverse exposomes associate with poorer cognition in healthy aging. In dementia, more complex exposomes correlate with lower cognitive and functional performance, higher neuropsychiatric symptoms, and brain structural and connectivity alterations in frontal-temporal-limbic and cerebellar regions. Food insecurity, financial resources, subjective socioeconomic status, and access to healthcare emerge as critical predictors. Cumulative exposome measures surpass isolated factors in predicting clinical-cognitive profiles. Multiple sensitivity analyses confirm our results. Findings highlight the need for personalized approaches integrating MSE across the lifespan, emphasizing prevention and interventions targeting social disparities.
dc.description.versionVersión Publicada
dc.identifier.citationMigeot J, Pina-Escudero SD, Hernandez H, Gonzalez-Gomez R, Legaz A, Fittipaldi S, Resende EPF, Duran-Aniotz C, Avila-Funes JA, Behrens MI, Bruno MA, Cardona JF, Custodio N, García AM, Godoy ME, Hu K, Lanata S, Lawlor B, Lopera F, Maito MA, Matallana DL, Miller B, Jaime Miranda J, de Oliveira MO, Reyes P, Santamaria-Garcia H, Slachevsky A, Sosa AL, Takada LT, Torres JM, Vanneste S, Valcour V, Wen O, Yokoyama JS, Possin KL, Ibanez A. Social exposome and brain health outcomes of dementia across Latin America. Nat Commun. 2025 Sep 11;16(1):8196. doi: 10.1038/s41467-025-63277-6
dc.identifier.doihttps://doi.org/10.1038/s41467-025-63277-6
dc.identifier.urihttps://hdl.handle.net/11447/10864
dc.language.isoen
dc.subjectAlzheimer Disease / epidemiology
dc.subjectAged
dc.subject80 and over
dc.subjectAlzheimer Disease / physiopathology
dc.subjectBrain* / physiopathology
dc.subjectDementia* / physiopathology
dc.subjectExposome
dc.subjectLatin America / epidemiology
dc.titleSocial exposome and brain health outcomes of dementia across Latin America
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourceNature communications
dspace.entity.typePublication
relation.isAuthorOfPublicationb0cb6d05-60d8-4c6f-96ed-e0bd1460aa3c
relation.isAuthorOfPublicatione25c3d3e-63b5-4e04-951a-12a4989aa772
relation.isAuthorOfPublication.latestForDiscoveryb0cb6d05-60d8-4c6f-96ed-e0bd1460aa3c

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