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Adverse maternal, fetal, and newborn outcomes among pregnant women with SARS- CoV- 2 infection: an individual participant data meta- analysis

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dc.contributor.authorSmith, Emily R.
dc.contributor.authorOakley, Erin
dc.contributor.authorWable Grandner, Gargi
dc.contributor.authorFerguson, Kacey
dc.contributor.authorFarooq, Fouzia
dc.contributor.authorAfshar, Yalda
dc.contributor.authorAhlberg, Mia
dc.contributor.authorAhmadzia, Homa
dc.contributor.authorAkelo, Victor
dc.contributor.authorAldrovandi, Grace
dc.contributor.authorTippett Barr, Beth A.
dc.contributor.authorBevilacqua, Elisa
dc.contributor.authorBrandt, Justin S.
dc.contributor.authorBroutet, Nathalie
dc.contributor.authorFernández Buhigas, Irene
dc.contributor.authorCarrillo Termini, Jorge
dc.contributor.authorClifton, Rebecca
dc.contributor.authorConry, Jeanne
dc.contributor.authorCosmi, Erich
dc.contributor.authorCrispi, Fatima
dc.contributor.authorCrovetto, Francesca
dc.contributor.authorDelgado-López, Camille
dc.contributor.authorDivakar, Hema
dc.contributor.authorDriscoll, Amanda J.
dc.contributor.authorFavre, Guillaume
dc.contributor.authorFlaherman, Valerie J.
dc.contributor.authorGale, Chris
dc.contributor.authorGil, Maria M.
dc.contributor.authorGottlieb, Sami L.
dc.contributor.authorGratacós, Eduard
dc.contributor.authorHernandez, Olivia
dc.contributor.authorJones, Stephanie
dc.contributor.authorKalafat, Erkan
dc.contributor.authorKhagayi, Sammy
dc.contributor.authorKnight, Marian
dc.contributor.authorKotloff, Karen
dc.contributor.authorLanzone, Antonio
dc.contributor.authorLe Doare, Kirsty
dc.contributor.authorLees, Christoph
dc.contributor.authorLitman, Ethan
dc.date.accessioned2024-05-31T21:16:39Z
dc.date.available2024-05-31T21:16:39Z
dc.date.issued2023
dc.descriptionErica M Lokken, Valentina Laurita Longo, Shabir A Madhi, Laura A Magee, Raigam Jafet Martinez-Portilla, Elizabeth M McClure, Tori D Metz, Emily S Miller, Deborah Money, Sakita Moungmaithong, Edward Mullins, Jean B Nachega, Marta C Nunes, Dickens Onyango, Alice Panchaud, Liona C Poon, Daniel Raiten, Lesley Regan, Gordon Rukundo, Daljit Sahota, Allie Sakowicz, Jose Sanin-Blair, Jonas Söderling, Olof Stephansson, Marleen Temmerman, Anna Thorson, Jorge E Tolosa, Julia Townson, Miguel Valencia-Prado, Silvia Visentin, Peter von Dadelszen, Kristina Adams Waldorf, Clare Whitehead, Murat Yassa, Jim M Tielsch; Perinatal COVID PMA Study Collaborators; Perinatal COVID PMA Study Collaborators
dc.description.abstractIntroduction Despite a growing body of research on the risks of SARS-CoV-2 infection during pregnancy, there is continued controversy given heterogeneity in the quality and design of published studies. Methods We screened ongoing studies in our sequential, prospective meta-analysis. We pooled individual participant data to estimate the absolute and relative risk (RR) of adverse outcomes among pregnant women with SARS-CoV-2 infection, compared with confirmed negative pregnancies. We evaluated the risk of bias using a modified Newcastle-Ottawa Scale. Results We screened 137 studies and included 12 studies in 12 countries involving 13 136 pregnant women. Pregnant women with SARS-CoV-2 infection—as compared with uninfected pregnant women—were at significantly increased risk of maternal mortality (10 studies; n=1490; RR 7.68, 95% CI 1.70 to 34.61); admission to intensive care unit (8 studies; n=6660; RR 3.81, 95% CI 2.03 to 7.17); receiving mechanical ventilation (7 studies; n=4887; RR 15.23, 95% CI 4.32 to 53.71); receiving any critical care (7 studies; n=4735; RR 5.48, 95% CI 2.57 to 11.72); and being diagnosed with pneumonia (6 studies; n=4573; RR 23.46, 95% CI 3.03 to 181.39) and thromboembolic disease (8 studies; n=5146; RR 5.50, 95% CI 1.12 to 27.12). Neonates born to women with SARS-CoV-2 infection were more likely to be admitted to a neonatal care unit after birth (7 studies; n=7637; RR 1.86, 95% CI 1.12 to 3.08); be born preterm (7 studies; n=6233; RR 1.71, 95% CI 1.28 to 2.29) or moderately preterm (7 studies; n=6071; RR 2.92, 95% CI 1.88 to 4.54); and to be born low birth weight (12 studies; n=11 930; RR 1.19, 95% CI 1.02 to 1.40). Infection was not linked to stillbirth. Studies were generally at low or moderate risk of bias. Conclusions This analysis indicates that SARS-CoV-2 infection at any time during pregnancy increases the risk of maternal death, severe maternal morbidities and neonatal morbidity, but not stillbirth or intrauterine growth restriction. As more data become available, we will update these findings per the published protocol.
dc.description.versionVersión aceptada
dc.format.extent37 p.
dc.identifier.citationSmith ER, Oakley E, Grandner GW, Ferguson K, Farooq F, Afshar Y, Ahlberg M, Ahmadzia H, Akelo V, Aldrovandi G, Tippett Barr BA, Bevilacqua E, Brandt JS, Broutet N, Fernández Buhigas I, Carrillo J, Clifton R, Conry J, Cosmi E, Crispi F, Crovetto F, Delgado-López C, Divakar H, Driscoll AJ, Favre G, Flaherman VJ, Gale C, Gil MM, Gottlieb SL, Gratacós E, Hernandez O, Jones S, Kalafat E, Khagayi S, Knight M, Kotloff K, Lanzone A, Le Doare K, Lees C, Litman E, Lokken EM, Laurita Longo V, Madhi SA, Magee LA, Martinez-Portilla RJ, McClure EM, Metz TD, Miller ES, Money D, Moungmaithong S, Mullins E, Nachega JB, Nunes MC, Onyango D, Panchaud A, Poon LC, Raiten D, Regan L, Rukundo G, Sahota D, Sakowicz A, Sanin-Blair J, Söderling J, Stephansson O, Temmerman M, Thorson A, Tolosa JE, Townson J, Valencia-Prado M, Visentin S, von Dadelszen P, Adams Waldorf K, Whitehead C, Yassa M, Tielsch JM; Perinatal COVID PMA Study Collaborators; Perinatal COVID PMA Study Collaborators. Adverse maternal, fetal, and newborn outcomes among pregnant women with SARS-CoV-2 infection: an individual participant data meta-analysis. BMJ Glob Health. 2023 Jan;8(1):e009495. doi: 10.1136/bmjgh-2022-009495.
dc.identifier.doihttps://doi.org/10.1136/bmjgh-2022-009495
dc.identifier.urihttps://hdl.handle.net/11447/8982
dc.language.isoen
dc.rightsAtribución-NoComercial-CompartirIgual 3.0 Chile (CC BY-NC-SA 3.0 CL)
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/cl/
dc.subjectCOVID-19
dc.subjectEpidemiology
dc.subjectMaternal health
dc.titleAdverse maternal, fetal, and newborn outcomes among pregnant women with SARS- CoV- 2 infection: an individual participant data meta- analysis
dc.typeArticle
dcterms.accessRightsAcceso abierto
dcterms.sourceBMJ Global Health
dspace.entity.typePublication
relation.isAuthorOfPublication423ecc04-599a-4f1c-8773-72bd3b556bdb
relation.isAuthorOfPublication.latestForDiscovery423ecc04-599a-4f1c-8773-72bd3b556bdb

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