Publication: Early high‑sensitivity troponin elevation and short‑term mortality in sepsis: a systematic review with meta‑analysis
| dc.contributor.author | Gajardo, Abraham I. J. | |
| dc.contributor.author | Ferrière‑Steinert, Santiago | |
| dc.contributor.author | Valenzuela Jiménez, Joaquín | |
| dc.contributor.author | Heskia Araya, Sebastián | |
| dc.contributor.author | Kouyoumdjian Carvajal, Thomas | |
| dc.contributor.author | Ramos‑Rojas, José | |
| dc.contributor.author | Medel, Juan Nicolás | |
| dc.date.accessioned | 2026-07-22T21:42:36Z | |
| dc.date.available | 2026-07-22T21:42:36Z | |
| dc.date.issued | 2025 | |
| dc.description.abstract | Background Serum cardiac troponin (cTn) elevation is a well-established phenomenon in sepsis. However, the clinical significance of this phenomenon with high-sensitivity (hs) assays and the current sepsis definition needs to be settled. Research Question What is the association between early serum cTn levels measured by hs-assays and the risk of short-term mortality in septic patients? Study Design and Methods We conducted a systematic review using a comprehensive PubMed, Scopus, and Embase search. Studies were eligible if they reported association data on early hs-cTn and mortality in an adult sample with sepsis that met the Sepsis-3 definition. For the synthesis of the effect of hs-cTn on mortality, we applied random effect models on the pooled unadjusted and adjusted odds ratio (OR and aOR, respectively) of elevated vs. normal hs-cTn serum values, and on the crude standardized mean difference (SMD) of hs-cTn between survivors and non-survivors. Results In total, 6242 patients from 17 studies were included, with short-term mortality rates ranging from 16.9% to 53.8%. Using a crude analysis, non-survivor patients showed higher hs-cTn than survivors (SMD of 0.87, 95%CI: 0.41–1.33). Elevated hs-cTn was associated with increased mortality (OR = 1.78, 95% CI: 1.41–2.25). However, this prognostic effect was absent in studies that adjusted for different confounders (aOR = 1.06, 95% CI: 0.99–1.14). Discussion and Conclusions Non-survivors of sepsis exhibited significantly elevated hs-cTn levels. While elevated hs-cTn levels are associated with an increased risk of mortality, they are not independently associated with this outcome in sepsis. | |
| dc.description.version | Versión publicada | |
| dc.format.extent | 12 p. | |
| dc.identifier.citation | Gajardo, A.I.J., Ferrière-Steinert, S., Valenzuela Jiménez, J. et al. Early high-sensitivity troponin elevation and short-term mortality in sepsis: a systematic review with meta-analysis. Crit Care 29, 76 (2025). https://doi.org/10.1186/s13054-025-05249-2 | |
| dc.identifier.doi | https://doi.org/10.1186/s13054-025-05249-2 | |
| dc.identifier.uri | https://hdl.handle.net/11447/10899 | |
| dc.language.iso | en | |
| dc.subject | High-sensitivity troponin | |
| dc.subject | Meta-analysis | |
| dc.subject | Prognosis | |
| dc.subject | Prognostic factor | |
| dc.subject | Sepsis | |
| dc.subject | Septic cardiomyopathy | |
| dc.subject | Septic shock | |
| dc.subject | Systematic review | |
| dc.subject | Troponin | |
| dc.title | Early high‑sensitivity troponin elevation and short‑term mortality in sepsis: a systematic review with meta‑analysis | |
| dc.type | Article | |
| dcterms.accessRights | Acceso abierto | |
| dcterms.source | Critical Care | |
| dspace.entity.type | Publication |