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Quantitative Susceptibility Mapping MRI in Deep-Brain Nuclei in First-Episode Psychosis

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dc.contributor.authorGarcía Saborit, Marisleydis
dc.contributor.authorJara, Alejandro
dc.contributor.authorMuñoz, Néstor
dc.contributor.authorMilovic, Carlos
dc.contributor.authorTepper, Angeles
dc.contributor.authorAlliende, Luz María
dc.contributor.authorMena, Carlos
dc.contributor.authorIruretagoyena, Bárbara
dc.contributor.authorRamírez-Mahaluf, Juan Pablo
dc.contributor.authorDíaz, Camila
dc.contributor.authorNachar, Ruben
dc.contributor.authorCastañeda, Carmen Paz
dc.contributor.authorGonzález, Alfonso
dc.contributor.authorUndurraga, Juan
dc.contributor.authorCrossley, Nicolás
dc.contributor.authorTejos, Cristian
dc.date.accessioned2024-05-27T20:36:28Z
dc.date.available2024-05-27T20:36:28Z
dc.date.issued2023
dc.description.abstractBackground: Psychosis is related to neurochemical changes in deep-brain nuclei, particularly suggesting dopamine dysfunctions. We used an magnetic resonance imaging-based technique called quantitative susceptibility mapping (QSM) to study these regions in psychosis. QSM quantifies magnetic susceptibility in the brain, which is associated with iron concentrations. Since iron is a cofactor in dopamine pathways and co-localizes with inhibitory neurons, differences in QSM could reflect changes in these processes. Methods: We scanned 83 patients with first-episode psychosis and 64 healthy subjects. We reassessed 22 patients and 21 control subjects after 3 months. Mean susceptibility was measured in 6 deep-brain nuclei. Using linear mixed models, we analyzed the effect of case-control differences, region, age, gender, volume, framewise displacement (FD), treatment duration, dose, laterality, session, and psychotic symptoms on QSM. Results: Patients showed a significant susceptibility reduction in the putamen and globus pallidus externa (GPe). Patients also showed a significant R2* reduction in GPe. Age, gender, FD, session, group, and region are significant predictor variables for QSM. Dose, treatment duration, and volume were not predictor variables of QSM. Conclusions: Reduction in QSM and R2* suggests a decreased iron concentration in the GPe of patients. Susceptibility reduction in putamen cannot be associated with iron changes. Since changes observed in putamen and GPe were not associated with symptoms, dose, and treatment duration, we hypothesize that susceptibility may be a trait marker rather than a state marker, but this must be verified with long-term studies.
dc.description.versionVersión publicada
dc.format.extent9 p.
dc.identifier.citationGarcía Saborit M, Jara A, Muñoz N, Milovic C, Tepper A, Alliende LM, Mena C, Iruretagoyena B, Ramirez-Mahaluf JP, Diaz C, Nachar R, Castañeda CP, González A, Undurraga J, Crossley N, Tejos C. Quantitative Susceptibility Mapping MRI in Deep-Brain Nuclei in First-Episode Psychosis. Schizophr Bull. 2023 Sep 7;49(5):1355-1363. doi: 10.1093/schbul/sbad041.
dc.identifier.doihttps://doi.org/10.1093/schbul/sbad041
dc.identifier.urihttps://hdl.handle.net/11447/8891
dc.language.isoen
dc.subjectQSM
dc.subjectR2*rates
dc.subjectDopamine
dc.subjectMagnetic susceptibility
dc.subjectNeuromelanin
dc.titleQuantitative Susceptibility Mapping MRI in Deep-Brain Nuclei in First-Episode Psychosis
dc.typeArticle
dcterms.accessRightsAcceso abierto
dcterms.sourceSchizophrenia Bulletin
dspace.entity.typePublication
relation.isAuthorOfPublication7a9f060d-7506-44d2-84ae-30bce0fea90a
relation.isAuthorOfPublication.latestForDiscovery7a9f060d-7506-44d2-84ae-30bce0fea90a

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