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Priorities and Progress in Gram-positive Bacterial Infection Research by the Antibacterial Resistance Leadership Group: A Narrative Review

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dc.contributor.authorDoernberg, Sarah
dc.contributor.authorArias, Cesar
dc.contributor.authorAltman, Deena
dc.contributor.authorBabiker, Ahmed
dc.contributor.authorBoucher, Helen
dc.contributor.authorCreech, C Buddy
dc.contributor.authorCosgrove, Sara
dc.contributor.authorEvans, Scott
dc.contributor.authorFowler, Vance
dc.contributor.authorFritz, Stephanie
dc.contributor.authorHamasaki, Toshimitsu
dc.contributor.authorKelly, Brendan
dc.contributor.authorLeal, Sixto
dc.contributor.authorLiu, Catherine
dc.contributor.authorLodise, Thomas
dc.contributor.authorMiller, Loren
dc.contributor.authorMunita, Jose M.
dc.contributor.authorMurray, Barbara
dc.contributor.authorPettigrew, Melinda
dc.contributor.authorRuffin, Felicia
dc.contributor.authorScheetz, Marc
dc.contributor.authorShopsin, Bo
dc.contributor.authorTran, Truc
dc.contributor.authorTurne, Nicholas
dc.contributor.authorWilliams, Derek
dc.contributor.authorZaharoff, Smitha
dc.contributor.authorHolland, Thomas
dc.contributor.authorAntibacterial Resistance Leadership Group
dc.date.accessioned2024-05-29T21:08:41Z
dc.date.available2024-05-29T21:08:41Z
dc.date.issued2023
dc.description.abstractThe Antibacterial Resistance Leadership Group (ARLG) has prioritized infections caused by gram-positive bacteria as one of its core areas of emphasis. The ARLG Gram-positive Committee has focused on studies responding to 3 main identified research priorities: (1) investigation of strategies or therapies for infections predominantly caused by gram-positive bacteria, (2) evaluation of the efficacy of novel agents for infections caused by methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci, and (3) optimization of dosing and duration of antimicrobial agents for gram-positive infections. Herein, we summarize ARLG accomplishments in gram-positive bacterial infection research, including studies aiming to (1) inform optimal vancomycin dosing, (2) determine the role of dalbavancin in MRSA bloodstream infection, (3) characterize enterococcal bloodstream infections, (4) demonstrate the benefits of short-course therapy for pediatric community-acquired pneumonia, (5) develop quality of life measures for use in clinical trials, and (6) advance understanding of the microbiome. Future studies will incorporate innovative methodologies with a focus on interventional clinical trials that have the potential to change clinical practice for difficult-to-treat infections, such as MRSA bloodstream infections.
dc.description.versionPublicada
dc.identifier.citationDoernberg SB, Arias CA, Altman DR, Babiker A, Boucher HW, Creech CB, Cosgrove SE, Evans SR, Fowler VG, Fritz SA, Hamasaki T, Kelly BJ, Leal SM, Liu C, Lodise TP, Miller LG, Munita JM, Murray BE, Pettigrew MM, Ruffin F, Scheetz MH, Shopsin B, Tran TT, Turner NA, Williams DJ, Zaharoff S, Holland TL; Antibacterial Resistance Leadership Group. Priorities and Progress in Gram-positive Bacterial Infection Research by the Antibacterial Resistance Leadership Group: A Narrative Review. Clin Infect Dis. 2023 Oct 16;77(Suppl 4):S295-S304. doi: 10.1093/cid/ciad565
dc.identifier.doihttps://doi.org/10.1093/cid/ciad565
dc.identifier.urihttps://hdl.handle.net/11447/8942
dc.language.isoen
dc.subjectAntibacterial agents
dc.subjectAntibacterial resistance
dc.subjectGram-positive bacterial infections
dc.subjectMethicillin-resistant Staphylococcus aureus
dc.subjectVancomycin-resistant enterococci
dc.titlePriorities and Progress in Gram-positive Bacterial Infection Research by the Antibacterial Resistance Leadership Group: A Narrative Review
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourceClinical infectious diseases : an official publication of the Infectious Diseases Society of America
dspace.entity.typePublication
relation.isAuthorOfPublicationec52b0bf-d0bc-4844-9531-eca4a65f2b8e
relation.isAuthorOfPublication.latestForDiscoveryec52b0bf-d0bc-4844-9531-eca4a65f2b8e

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