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Biofunctional Polyvinyl Alcohol/Xanthan Gum/Gelatin Hydrogel Dressings Loaded with Curcumin: Antibacterial Properties and Cell Viability

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dc.contributor.authorRivera, María
dc.contributor.authorCament, Alejandro
dc.contributor.authorAhumada, Manuel
dc.contributor.authorCorrales, Teresa
dc.contributor.authorGarcía, Verónica
dc.contributor.authorPablos, Jesús
dc.contributor.authorOsorio, Javiera
dc.contributor.authorRamos, Giselle
dc.contributor.authorVargas, Leslie
dc.contributor.authorMarcelo Ezquer
dc.contributor.authorEzquer, Marcelo
dc.contributor.authorOrtiz, J. Andrés
dc.date.accessioned2026-07-21T21:46:45Z
dc.date.available2026-07-21T21:46:45Z
dc.date.issued2025
dc.description.abstractThis study explores the development of biocompatible hydrogel dressings incorporating curcumin as an alternative antibacterial agent. In this context, hydrogels were prepared using polyvinyl alcohol, xanthan gum, gelatin, and curcumin as a therapeutic component. FTIR spectroscopy confirmed the successful incorporation of curcumin into the hydrogel matrix, while release profiles demonstrated sustained release. Mechanical testing indicated that xanthan gum reduced elongation and strength in hydrogels, while the combination of xanthan gum and gelatin increased stiffness without loss of elasticity. Curcumin had no major effect on the tensile and rheological properties, preserving the structural integrity of the hydrogels. The hydrogels demonstrated antibacterial activity against Pseudomonas aeruginosa and Staphylococcus aureus ATCC strains, as well as multidrug methicillin-resistant Staphylococcus aureus (MRSA) clinical isolates. Biocompatibility was confirmed through viability assays with immortalized human keratinocytes (HaCaT) and adult human dermal fibroblasts (HDFa), showing no acute cytotoxic effects after 48 h of exposure. Their effective action against clinically relevant bacteria and high cytocompatibility position these hydrogels as promising candidates for infection management and antibiotic resistance mitigation in wound care applications.
dc.description.versionVersión Publicada
dc.identifier.citationRivera MJ, Cament A, Ahumada M, Corrales T, García V, Pablos JL, Osorio J, Ramos-González G, Vargas-Saturno L, Ezquer M, Ortiz JA. Biofunctional Polyvinyl Alcohol/Xanthan Gum/Gelatin Hydrogel Dressings Loaded with Curcumin: Antibacterial Properties and Cell Viability. Gels. 2025 Sep 23;11(10):764. doi: 10.3390/gels11100764
dc.identifier.doihttps://doi.org/10.3390/gels11100764
dc.identifier.urihttps://hdl.handle.net/11447/10890
dc.language.isoen
dc.titleBiofunctional Polyvinyl Alcohol/Xanthan Gum/Gelatin Hydrogel Dressings Loaded with Curcumin: Antibacterial Properties and Cell Viability
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourceGels
dspace.entity.typePublication
relation.isAuthorOfPublication9cd4a8e6-6ba1-4344-80a2-45c260864d4c
relation.isAuthorOfPublication.latestForDiscovery9cd4a8e6-6ba1-4344-80a2-45c260864d4c

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