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Asymptomatic herpes simplex virus brain infection elicits cellular senescence phenotypes in the central nervous system of mice suffering multiple sclerosis-like disease

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dc.contributor.authorDuarte, Luisa
dc.contributor.authorVillalobos, Verónica
dc.contributor.authorFarías, Mónica
dc.contributor.authorRangel, Maria
dc.contributor.authorGonzález, Enrique
dc.contributor.authorNavarro, Areli
dc.contributor.authorCarbone, Javier
dc.contributor.authorDomínguez, Angélica
dc.contributor.authorAlvarez, Alejandra
dc.contributor.authorRiedel, Claudia
dc.contributor.authorBueno, Susan
dc.contributor.authorKalergis, Alexis
dc.contributor.authorCáceres, Mónica
dc.contributor.authorGonzález, Pablo
dc.date.accessioned2025-01-13T19:06:48Z
dc.date.available2025-01-13T19:06:48Z
dc.date.issued2024
dc.description.abstractExperimental autoimmune encephalomyelitis (EAE) is a demyelinating disease affecting the central nervous system (CNS) in animals that parallels several clinical and molecular traits of multiple sclerosis in humans. Herpes simplex virus type 1 (HSV-1) infection mainly causes cold sores and eye diseases, yet eventually, it can also reach the CNS, leading to acute encephalitis. Notably, a significant proportion of healthy individuals are likely to have asymptomatic HSV-1 brain infection with chronic brain inflammation due to persistent latent infection in neurons. Because cellular senescence is suggested as a potential factor contributing to the development of various neurodegenerative disorders, including multiple sclerosis, and viral infections may induce a premature senescence state in the CNS, potentially increasing susceptibility to such disorders, here we examine the presence of senescence-related markers in the brains and spinal cords of mice with asymptomatic HSV-1 brain infection, EAE, and both conditions. Across all scenarios, we find a significant increases of senescence biomarkers in the CNS with some differences depending on the analyzed group. Notably, some senescence biomarkers are exclusively observed in mice with the combined conditions. These results indicate that asymptomatic HSV-1 brain infection and EAE associate with a significant expression of senescence biomarkers in the CNS.
dc.description.versionVersión Publicada
dc.identifier.citationDuarte LF, Villalobos V, Farías MA, Rangel-Ramírez MA, González-Madrid E, Navarro AJ, Carbone-Schellman J, Domínguez A, Alvarez A, Riedel CA, Bueno SM, Kalergis AM, Cáceres M, González PA. Asymptomatic herpes simplex virus brain infection elicits cellular senescence phenotypes in the central nervous system of mice suffering multiple sclerosis-like disease. Commun Biol. 2024 Jul 4;7(1):811. doi: 10.1038/s42003-024-06486-x
dc.identifier.doihttps://doi.org/10.1038/s42003-024-06486-x
dc.identifier.urihttps://hdl.handle.net/11447/9635
dc.language.isoen
dc.subjectCentral Nervous System / metabolism
dc.subjectCentral Nervous System / pathology
dc.subjectCentral Nervous System / virology
dc.subjectEncephalitis
dc.subjectHerpes Simplex / metabolism
dc.subjectHerpes Simplex / pathology
dc.subjectEncephalomyelitis
dc.subjectAutoimmune
dc.subjectExperimental / metabolism
dc.subjectHerpes Simplex* / pathology
dc.subjectHerpes Simplex* / virology
dc.titleAsymptomatic herpes simplex virus brain infection elicits cellular senescence phenotypes in the central nervous system of mice suffering multiple sclerosis-like disease
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourceCommunications biology
dspace.entity.typePublication

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