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Royal jelly extracellular vesicles promote wound healing by modulating underlying cellular responses

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dc.contributor.authorÁlvarez, Simón
dc.contributor.authorContreras, Pamina
dc.contributor.authorAguayo, Sebastian
dc.contributor.authorRamírez, Orlando
dc.contributor.authorVallejos, Catalina
dc.contributor.authorRuiz, Jorge
dc.contributor.authorCarrasco, Eva
dc.contributor.authorTroncoso, Stefanie
dc.contributor.authorMorales, Bernardo
dc.contributor.authorSchuh, Christina
dc.date.accessioned2024-06-03T19:47:20Z
dc.date.available2024-06-03T19:47:20Z
dc.date.issued2023
dc.description.abstractApis mellifera royal jelly (RJ) is a well-known remedy in traditional medicine around the world and its versatile effects range from antibacterial to anti-inflammatory properties and pro-regenerative properties. As a glandular product, RJ has been shown to contain a substantial number of extracellular vesicles (EVs), and, in this study, we aimed to investigate the extent of involvement of RJEVs in wound healing-associated effects. Molecular analysis of RJEVs verified the presence of exosomal markers such as CD63 and syntenin, and cargo molecules MRJP1, defensin-1, and jellein-3. Furthermore, RJEVs were demonstrated to modulate mesenchymal stem cell (MSC) differentiation and secretome, as well as decrease LPS-induced inflammation in macrophages by blocking the mitogen-activated protein kinase (MAPK) pathway. In vivo studies confirmed antibacterial effects of RJEVs and demonstrated an acceleration of wound healing in a splinted mouse model. This study suggests that RJEVs play a crucial role in the known effects of RJ by modulating the inflammatory phase and cellular response in wound healing. Transfer of RJ into the clinics has been impeded by the high complexity of the raw material. Isolating EVs from the raw RJ decreases the complexity while allowing standardization and quality control, bringing a natural nano-therapy one step closer to the clinics.
dc.description.versionAceptada
dc.identifier.citationÁlvarez S, Contreras-Kallens P, Aguayo S, Ramírez O, Vallejos C, Ruiz J, Carrasco-Gallardo E, Troncoso-Vera S, Morales B, Schuh CMAP. Royal jelly extracellular vesicles promote wound healing by modulating underlying cellular responses. Mol Ther Nucleic Acids. 2023 Feb 14;31:541-552. doi: 10.1016/j.omtn.2023.02.008
dc.identifier.doihttps://doi.org/10.1016/j.omtn.2023.02.008
dc.identifier.urihttps://hdl.handle.net/11447/9000
dc.language.isoen
dc.subjectApis mellifera
dc.subjectMT: Special Issue - Exploiting Extracellular Vesicles as Therapeutic Agents
dc.subjectAnti-inflammatory extracellular vesicles
dc.subjectDefensin-1
dc.subjectExtracellular vesicle delivery
dc.subjectHoneybee
dc.subjectInterkingdom communication
dc.subjectNano-therapy
dc.subjectRegenerative medicine
dc.subjectTherapeutic extracellular vesicles
dc.titleRoyal jelly extracellular vesicles promote wound healing by modulating underlying cellular responses
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourceMolecular therapy. Nucleic acids
dspace.entity.typePublication

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