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Growth of Very Low Birth Weight Infants Who Received a Liquid Human Milk Fortifier: A Randomized, Controlled Multicenter Trial

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dc.contributor.authorMasoli, Daniela
dc.contributor.authorMena, Patricia
dc.contributor.authorDominguez, Angelica
dc.contributor.authorRamolfo, Pamela
dc.contributor.authorVernal, Patricia
dc.contributor.authorPantoja, Miguel Angel
dc.contributor.authorEsparza, Ruth
dc.contributor.authorHübner, ME
dc.contributor.authorRíos, Antonio
dc.contributor.authorFaunes, Miriam
dc.contributor.authorUauy, Ricardo
dc.contributor.authorTapia, Jose L.
dc.date.accessioned2023-07-07T15:37:00Z
dc.date.available2023-07-07T15:37:00Z
dc.date.issued2022
dc.description
dc.description.abstractObjectives: To evaluate growth (weight, length, head circumference, and knee–heel length [KHL]) in very low birth weight (VLBW) infants (500–1500 g) who received human milk with a liquid fortifier (LHMF) with high protein and fatty acid content versus a traditional powder fortifier (PHMF) for 45 days or until discharge. Methods: This was a multicenter, randomized, controlled trial. An intention-to-treat analysis was performed to determine adverse events and withdrawal causes. We also performed an efficacy analysis involving the infants who completed at least 2 weeks of study. Results: Of the 158 infants enrolled in the study, 146 completed at least 2 weeks, and 125 completed the entire study. The biodemographic characteristics were similar between groups, with no differences in increments of weight (22.9 vs 22.7 g kg1 day1 ), length (1.03 vs 1.09 cm/week), head circumference (0.91 vs 0.90 cm/week), or KHL (3.6 vs 3.3 mm/week). The KHL increment was greater in infants weighing >1 kg receiving LHMF (3.7 vs 3.2 mm/week, P ¼ 0.027). Although there were no significant differences in serious adverse events, the incidence difference of the composite outcome death/necrotizing enterocolitis between groups warrants attention (1.3% with LHMF and 8.1% with PHMF). Conclusion: There were no differences in the overall growth between VLBW infants receiving either fortifier.
dc.description.versionVersión aceptada
dc.format.extent7 p.
dc.identifier.citationJournal of Pediatric Gastroenterology and Nutrition 74(3):p 424-430, March 2022.
dc.identifier.doihttps://doi.org/10.1097/MPG.0000000000003321
dc.identifier.urihttps://repositorio.udd.cl/handle/11447/7651
dc.language.isoen
dc.subjectHuman milk fortifiers
dc.subjectNeonatal nutrition
dc.subjectRandomized controlled trial
dc.subjectVery low birthweight infants
dc.titleGrowth of Very Low Birth Weight Infants Who Received a Liquid Human Milk Fortifier: A Randomized, Controlled Multicenter Trial
dc.typeArticle
dcterms.accessRightsPrivado
dspace.entity.typePublication

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