Person:
Delgado, Iris

Profile Picture

Email Address

Birth Date

Research Projects

Organizational Units

Job Title

Last Name

Delgado

First Name

Iris

Name

Filters

2022 - 20246
Reset filters

Settings

¿Qué estás buscando?



Start date: 2020 ×

Search Results

Now showing 1 - 6 of 6
  • Thumbnail Image
    Publication
  • Thumbnail Image
    Publication
    Assessing Pulmonary Epithelial Damage in Hantavirus Cardiopulmonary Syndrome: Challenging the Predominant Role of Vascular Endothelium through sRAGE as a Potential Biomarker
    (2023) Meza, Gabriela; López, René; Vial Cox, María Cecilia; Cortes, Lina; Retamal, Mauricio A.; Delgado, Iris
    Hantavirus cardiopulmonary syndrome (HCPS) is a severe respiratory illness primarily associated with microvascular endothelial changes, particularly in the lungs. However, the role of the pulmonary epithelium in HCPS pathogenesis remains unclear. This study explores the potential of soluble Receptors for Advanced Glycation End-products (sRAGE) as a biomarker for assessing pulmonary epithelial damage in severe HCPS, challenging the prevailing view that endothelial dysfunction is the sole driver of this syndrome. We conducted a cross-sectional study on critically ill HCPS patients, categorizing them into mild HCPS, severe HCPS, and negative control groups. Plasma sRAGE levels were measured, revealing significant differences between the severe HCPS group and controls. Our findings suggest that sRAGE holds promise as an indicator of pulmonary epithelial injury in HCPS and may aid in tracking disease progression and guiding therapeutic strategies. This study brings clarity on the importance of investigating the pulmonary epithelium's role in HCPS pathogenesis, offering potential avenues for enhanced diagnostic precision and support in this critical public health concern.
  • Thumbnail Image
    Publication
    Exposure of 4- year to 24- year olds to tobacco imagery on prime- time Chilean television
    (2023) Peruga, Armando; Oscar Urrejola; Delgado, Iris; Matute, María Isabel; Castillo-Laborde, Carla; Molina, Xaviera; Hirmas Adauy, Macarena; Olea, Andrea; González, Claudia; Aguilera, Ximena; Sargent, James
    Introduction: The extent of the population's exposure to tobacco imagery across all genres of regular TV programming and the contribution of each of these genres is unknown, except for UK broadcast channels. The objective of this study is to estimate the exposure of young people to tobacco imagery on Chilean prime-time television and the programme source contributing to such exposure. Methods: Programmes aired during 3 weeks in 2019 from the 15 highest audience channels in Chile were content-analysed for the occurrence of tobacco categorised as actual use, implied use, tobacco paraphernalia, tobacco brand appearances and whether they violated Chilean smoke-free law for each 1 min interval (92 639). The exposure of young people to tobacco content was estimated using media viewership figures. Results: Young people received 29, 11 and 4 million tobacco impressions of any type, explicit use and smoke-free violation, respectively, at a rate of 21.8, 8.0 and 2.1 thousand impressions per hour of TV viewing. The main sources of exposure to tobacco impressions were feature films and animated productions, which were almost entirely non-Chilean. Finally, young people were exposed to tobacco brand impressions primarily through films, effectively circumventing the advertising ban in Chile. Discussion: Television programming is a source of significant youth exposure to tobacco imagery, including branding impressions. To conform to the WHO FCTC, Chile should prohibit tobacco branding in any TV programme and require strong anti-tobacco advertisements prior to any TV programme portraying tobacco.
  • Thumbnail Image
    Publication
    Comparative analysis of COVID-19 diagnoses and mortality among hospitalized indigenous and non-indigenous populations in Chile: 2020-2021
    (2024) Dahal, Sushma; Delgado, Iris; Sattenspiel, Lisa; Mamelund, Svenn; Chowell, Gerardo
    Background: Current literature presents mixed effects of the COVID-19 pandemic on Indigenous communities. We aim to highlight potential disparities and temporal shifts in both the impact of COVID-19 and vaccine uptake among hospitalized Indigenous populations in Chile. Methods: We conducted an observational analysis utilizing 1,598,492 hospitalization records from 2020 to 2021 based on publicly accessible hospital discharge data spanning 65 healthcare facilities of medium and high complexity funded through the Diagnosis-Related Groups (DRG) mechanism in Chile, representing roughly 70% of the country's total hospitalizations. This was supplemented with publicly available municipal data on COVID-19 vaccinations and socio-demographic variables. We performed logistic regression analysis at 0.05 level of significance to assess the bivariate and multivariable association of Indigenous status with COVID-19 diagnosis and COVID-19 deaths among hospitalized populations. We also performed univariate and multiple linear regression to assess the association of COVID-19 vaccination rate and Indigenous status at the municipality level. In addition, we report the distribution of top 10 secondary diagnoses among hospitalized COVID-19 cases and deaths separately for Indigenous and non-Indigenous populations. Results: Indigenous populations displayed lower adjusted odds for both COVID-19 diagnosis (OR: 0.76, 95% CI: 0.74, 0.77) and death (OR: 0.91, 95% CI: 0.85, 0.97) when compared to non-Indigenous groups. Notably, the adjusted odds ratio for COVID-19 diagnosis in Indigenous populations rose from 0.59 (95% CI: 0.57, 0.61) in 2020 to 1.17 (95% CI: 1.13, 1.21) in 2021. Factors such as the significantly higher median age and greater number of comorbidities in the non-Indigenous hospitalized groups could account for their increased odds of COVID-19 diagnosis and mortality. Additionally, our data indicates a significantly negative adjusted association between COVID-19 vaccination rates and the proportion of Indigenous individuals. Conclusion: Although Indigenous populations initially showed lower odds of COVID-19 diagnosis and mortality, a marked rise in diagnosis odds among these groups in 2021 underscores the urgency of targeted interventions. The observed negative association between the proportion of Indigenous populations and vaccination rates further underscores the necessity to tackle vaccine access barriers and work towards equitable distribution.
  • Thumbnail Image
    Publication
    Diagnostic imaging in Chile: population-based description of its use in hospitalized patients
    (2024) Cristi, Joaquín; Cocio, Rolando; Delgado, Iris; Blaskovic, Fernanda
    Introduction: The limited availability of data in Chile on the use of diagnostic images (DI) poses a challenge in the efficient management of resources. Objective: To quantify and characterize the use of DI in hospitalized subjects in Chile for 1 year. Method: Descriptive population based study on the use of DI in Chile during 2019 in hospitalized subjects using an official national database recorded with the diagnosis-related groups (DRG) system. Demographic variables related to hospitalization and derived from the DRG were analyzed. Results: 55.5% of hospital events involved at least one DI (n = 466,306). The most used imaging technique was radiography/X-ray (36.4%), followed by computed tomography (35%). The Magallanes and Aysén regions exhibited the highest DI rates. Hospitalized patients who required some DI had an average of days of hospitalization and mortality rate that were 3.4 and 5.5 times greater than those who did not require DI (p < 0.01). Conclusions: There are important geographical differences in the use of DI in Chile. Our description will facilitate future studies that delve deeper and explore access or socioeconomic differences. Introducción: La escasa disponibilidad de datos en Chile sobre el uso de imágenes diagnósticas (ID) plantea un desafío en la gestión eficiente de recursos. Objetivo: Cuantificar y caracterizar el uso de ID en sujetos hospitalizados en Chile durante 1 año. Método: Estudio poblacional descriptivo sobre el uso de ID en Chile durante el año 2019 en sujetos hospitalizados utilizando una base de datos nacional oficial consignada con la herramienta de grupos relacionados a diagnósticos (GRD). Se analizaron variables demográficas, relativas a la hospitalización y derivadas de los GRD. Resultados: El 55,5% de los eventos hospitalarios involucró al menos una ID (n = 466.306). La modalidad de imagen más utilizada fue la radiografía (36,4%), seguida por la tomografía computada (35%). Las regiones de Magallanes y Aysén exhibieron las tasas de ID más altas. Los pacientes hospitalizados que requirieron alguna ID obtuvieron unos promedios de días de hospitalización y letalidad 3,4 y 5,5 veces mayores que los que no requirieron ID (p < 0,01). Conclusiones: Existen importantes diferencias geográficas en la utilización de ID en Chile. Nuestra descripción facilitará la realización de futuros estudios que profundicen y exploren las diferencias en el acceso o socioeconómicas.
  • Thumbnail Image
    Publication
    Gallbladder cancer mortality in Chile: has the government program targeting young gallstone patients had an impact?
    (2024) Cid, Vicente; Vargas, Claudio; Delgado, Iris; Apablaza, Mauricio; Shiels, Meredith; Hildesheim, Allan; Koshiol, Jill; Ferreccio, Catterina

Implementado por OpenGeek Services