Browsing by Author "Truelsen, Thomas"

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    First-Ever Stroke and Transient Ischemic Attack Incidence and 30-Day Case-Fatality Rates in a Population-Based Study in Argentina
    (American Heart Association, Inc., 2016) Bahit, Cecilia; Coppola, Mariano; Riccio, Patricia; Cipriano, Lauren; Roth, Gregory; lopes, Renato; Feigin, Valery; Borrego, Brenda; De Martino, Maximiliano; Díaz, Alejandro; Ferrante, Daniel; Funaro, Fernando; Lavados, Pablo; Lewin, Laura; López, Daniel; Macarrone, Patricia; Marciello, Rafael; Marino, Diego; Martens, Cecilia; Martínez, Paula; Odriozola, Guillermo; Rabinstein, Alejandro; Saposnik, Gustavo; Silva, Damián; Suasnabar, Ramón; Truelsen, Thomas; Uzcudun, Araceli; Viviani, Carlos; Sposato, Luciano
    Epidemiological data about stroke are scarce in low- and middle-income Latin-American countries. We investigated annual incidence of first-ever stroke and transient ischemic attack (TIA) and 30-day case-fatality rates in a population-based setting in Tandil, Argentina. METHODS: We prospectively identified all first-ever stroke and TIA cases from overlapping sources between January 5, 2013, and April 30, 2015, in Tandil, Argentina. We calculated crude and standardized incidence rates. We estimated 30-day case-fatality rates. RESULTS: We identified 334 first-ever strokes and 108 TIAs. Age-standardized incidence rate per 100 000 for Segi's World population was 76.5 (95% confidence interval [CI], 67.8-85.9) for first-ever stroke and 25.1 (95% CI, 20.2-30.7) for first-ever TIA, 56.1 (95% CI, 48.8-64.2) for ischemic stroke, 13.5 (95% CI, 9.9-17.9) for intracerebral hemorrhage, and 4.9 (95% CI, 2.7-8.1) for subarachnoid hemorrhage. Stroke incidence was slightly higher for men (87.8; 95% CI, 74.6-102.6) than for women (73.2; 95% CI, 61.7-86.1) when standardized for the Argentinean population. Thirty-day case-fatality rate was 14.7% (95% CI, 10.8-19.5) for ischemic stroke, 24.1% (95% CI, 14.2-36.6) for intracerebral hemorrhage, and 1.9% (95% CI, 0.4-5.8) for TIA. CONCLUSIONS: This study provides the first prospective population-based stroke and TIA incidence and case-fatality estimate in Argentina. First-ever stroke incidence was lower than that reported in previous Latin-American studies, but first-ever TIA incidence was higher. Thirty-day case-fatality rates were similar to those of other population-based Latin-American studies.
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    Update on the Global Burden of Ischemic and Hemorrhagic Stroke in 1990-2013: The GBD 2013 Study
    (2015) Feigin, Valery L; Krishnamurthi, Rita V; Parmar, Priya; Norrving, Bo; Mensah, George A; Bennett, Derrick A; Barker-Collo, Suzanne; Moran, Andrew E; Sacco, Ralph L; Truelsen, Thomas; Davis, Stephen; Durai Pandian, Jeyaraj; Naghavi, Mohsen; Forouzanfar, Mohammad H; Nguyen, Grant; Johnson, Catherine O; Vos, Theo; Meretoja, Atte; Murray, Christopher J L; Roth, Gregory A; Ferede Abera, Semaw; Olusola Akinyemi, Rufus; Al-Shahi Salman, Rustam; Anderson, Craig S; Bahit, María Cecilia; Banerjeesela, Amitava; Basu, Sanjay; Beauchamp, Norman J; Bornstein, Natan; Brainin, Michael; Cabral, Norberto Luiz; Campos-Nonato, Ismael; Caso, Valeria; Catalá-López, Ferrán; Chowdhury, Rajiv; Christensen, Hanne K; Connor, Myles D; DeVeber, Gabrielle; Dharmaratne, Samath D; Dokova, Klara; Donnan, Geoffrey; Endres, Matthias; Gomes Fernandes, Jefferson; Gankpé, Fortuné; Geleijnse, Johanna M; Gillum, Richard F; Giroud, Maurice; Hamadeh, Randah R; Hankey, Graeme J; Jeemon, Panniyammakal; Jonas, Jost B; Kazi, Dhruv S; Kengne, Andre Pascal; Kim, Daniel; Kissela, Brett M; Kokubo, Yoshihiro; Kosen, Soewarta; Kravchenko, Michael; Lavados, Pablo
    Background: Global stroke epidemiology is changing rapidly. Although age-standardized rates of stroke mortality have decreased worldwide in the past 2 decades, the absolute numbers of people who have a stroke every year, and live with the consequences of stroke or die from their stroke, are increasing. Regular updates on the current level of stroke burden are important for advancing our knowledge on stroke epidemiology and facilitate organization and planning of evidence-based stroke care. Objectives: This study aims to estimate incidence, prevalence, mortality, disability-adjusted life years (DALYs) and years lived with disability (YLDs) and their trends for ischemic stroke (IS) and hemorrhagic stroke (HS) for 188 countries from 1990 to 2013. Methodology: Stroke incidence, prevalence, mortality, DALYs and YLDs were estimated using all available data on mortality and stroke incidence, prevalence and excess mortality. Statistical models and country-level covariate data were employed, and all rates were age-standardized to a global population. All estimates were produced with 95% uncertainty intervals (UIs). Results: In 2013, there were globally almost 25.7 million stroke survivors (71% with IS), 6.5 million deaths from stroke (51% died from IS), 113 million DALYs due to stroke (58% due to IS) and 10.3 million new strokes (67% IS). Over the 1990-2013 period, there was a significant increase in the absolute number of DALYs due to IS, and of deaths from IS and HS, survivors and incident events for both IS and HS. The preponderance of the burden of stroke continued to reside in developing countries, comprising 75.2% of deaths from stroke and 81.0% of stroke-related DALYs. Globally, the proportional contribution of stroke-related DALYs and deaths due to stroke compared to all diseases increased from 1990 (3.54% (95% UI 3.11-4.00) and 9.66% (95% UI 8.47-10.70), respectively) to 2013 (4.62% (95% UI 4.01-5.30) and 11.75% (95% UI 10.45-13.31), respectively), but there was a diverging trend in developed and developing countries with a significant increase in DALYs and deaths in developing countries, and no measurable change in the proportional contribution of DALYs and deaths from stroke in developed countries. Conclusion: Global stroke burden continues to increase globally. More efficient stroke prevention and management strategies are urgently needed to halt and eventually reverse the stroke pandemic, while universal access to organized stroke services should be a priority. © 2015 S. Karger AG, Basel.

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