Browsing by Author "Soza, Cristian"

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    Oncogenic role of arsenic exposure in lung cancer: A forgotten risk factor
    (2019) Soza, Cristian; Bustamante, Eva; Caglevic, Christian; Rolfo, Christian; Sirera, Rafael; Marsiglia, Hugo
    Several drinkable water sources worldwide have been highly contaminated with arsenic, which means that an estimated 160 million people have been exposed to this chemical agent. If we analyse exposure by region, we will find a high correlation between arsenic contamination and the incidence of lung cancer (among other malignancies). In order to determine what the risks of these exposures are, we need to understand how this chemical is processed in our body and how it is linked to cancer. In this article we reviewed how biotransformation of ingested arsenic may lead to cancer by modulating the activation of several essential signalling pathways such as EGFR, PI3K/AKT, RTK/Ras/PI3K, JNK/STAT3 and Nrf2-KEAP1; by producing epigenetics modifications and by disrupting normal expression of miRNAs. In order to design effective health policies, educational strategies, decontaminations plans and effective medical treatments are necessary to understand the impact of arsenic pollution and the relevance of the environment in our health.
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    Triple-negative breast cancer: the reality in Chile and in Latin America
    (2019) Caglevic, Christian; Anabalón, Jaime; Soza, Cristian; Milla, Elizabeth; Gaete, Fancy; Carrasco, Ana María; Panay, Sergio; Gallardo, Carlos; Mahave, Mauricio
    Breast cancer is the leading cause of cancer death among women worldwide. While triple-negative breast cancer is less common among various sub-types of breast cancer, it tends to affect younger women and is more aggressive, having a higher rate of early recurrence and mortality compared to other sub-types. We know about the association between triple-negative breast cancer and BRCA mutations, which are highly prevalent in founding populations of European origin, but the true prevalence of these mutations in Latin American populations is unknown. There is also very little information about the demographic and epidemiological aspects of triple-negative breast cancer in Latin America, which we will try to summarise in this article. In addition, we will try to provide a brief introduction to the most common recommendations for treating this histological class in Latin America.

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