Browsing by Author "Ramos, Mario"
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Item Desarrollo de un algoritmo para la generación y elección de soluciones de corte en la operación de canteo y despuntado en aserraderos(2011) Vergara, Francisco P.; Baesler, Felipe; Ramos, MarioIn this research work an algorithm that gathers the best procedures applied in sawmills was developed, along with a methodology based on cutting geometrical line analysis. This application was programmed under the C(++) language, sizes objective board and its prices, and the 2-D slab geometry are the input data, obtaining length and width solutions for every slab. Its outcomes have been compared with a pattern that matches the solutions provided by an "optimized" cutting machine in a southern sawmill in Chile. Four types of solutions were obtained when inputting slabs geometry, which was captured with four different reading steps. Outcomes show that solutions achieved with a reading width of 100 mm were 4% better in average than the pattern, and far better to other solutions achieved with the remaining 3 steps. Leaving aside the particular operating conditions of either method; a theoretical comparison of time by solution method, indicates that the 77 milliseconds SISCORMAD employed are significantly lower than those obtained with dynamic programming 320 milliseconds, 890 milliseconds with total enumeration, and 140 milliseconds obtained with geometric heuristic as solution times reported by [6]. This feature makes the developed algorithm very attractive for future applications. However, given the heuristic nature SISCORMAD, it is just a high quality solution, but not optimal.Item Evidence of hysteresis in propofol pharmacodynamics(John Wiley & Sons, 2017) Sepúlveda, Pablo; Carrasco, E; Tapia, Luis; Ramos, Mario; Cruz, F; Conget, Paulette; Olivares, Q; Cortinez, IIt is commonly assumed that loss of responsiveness and recovery of responsiveness occur at similar concentrations of propofol. However, the 'conscious' and 'anaesthetised' conditions produced by general anaesthetics may behave as two bistable states. We hypothesised that loss of responsiveness and recovery of responsiveness occur at different propofol concentrations. Propofol was administered to 19 healthy volunteers by effect-site target-controlled infusion using increasing and decreasing stable concentration steps of 7 min. Propofol serum concentrations were measured from venous blood samples at the end of each 7-min step. A long step of 14 min was performed at loss of responsiveness. At this step, propofol concentrations were measured at 7 and 14 min. Propofol concentrations measured at loss of responsiveness and recovery of responsiveness were 2.6 (1.2-4.7) μg.ml-1 and 1.6 (0.6-3.3) μg.ml-1 , respectively (p < 0.001). Propofol plasma concentration and the corresponding bispectral index values measured at minute 7 and minute 14 of the long step performed at loss of responsiveness were 2.6 (1.2-4.7) vs. 2.6 (1.3-4.3) at recovery of responsiveness, (p = 0.96) and 61.2 (49.0-77.0) vs. 58.4 (45.0-74.0), (p = 0.058), respectively. Loss of responsiveness and recovery of responsiveness appear to occur at different propofol concentrations. However, it is possible that, if equilibration was not achieved between plasma and effect-sites at the end of each 7-min step, the higher concentrations found at loss of responsiveness compared with those observed during recovery of responsiveness could be explained by a possible bias in estimations of the effect-site concentrations of propofol by the Schnider model, rather than neural inertia.