Browsing by Author "Quezada Diez, Mauricio Alejandro"
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Item Therapeutic effects of mesenchymal stem cell-derived secretome administration on morphine-induced consumption, relapse, and withdrawal in rats: Role of brain oxidative stress and neuroinflammation(Universidad del Desarrollo. Facultad de Medicina, 2023) Quezada Diez, Mauricio Alejandro; Ezquer, Fernando; Berríos-Cárcamo, PabloThis thesis presents the results obtained after the simultaneous intranasal and intravenous administration of the antioxidant and anti-inflammatory secretome generated from preconditioned hMSC on the precipitated (naloxone-induced) and spontaneous (oral model) withdrawal syndrome, the reduction in its chronic consumption, and the relapse to voluntary oral consumption (oral model) in rats exposed to continuous doses of opioids. Additionally, the association and role of oxidative stress and neuroinflammation in the different stages of morphine addiction were evaluated.