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Browsing by Author "Mardones, Felipe"

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    Advances in machine learning for tumour classification in cancer of unknown primary: A mini-review
    (2024) Oróstica, Karen; Mardones, Felipe; Bernal, Yanara; Molina, Samuel; Orchard, Marcos; Verdugo, Ricardo; Carvajal-Hausdorf, Daniel; Marcelain, Katherine; Contreras, Seba; Armisen, Ricardo
    Cancers of unknown primary (CUP) are a heterogeneous group of aggressive metastatic cancers where standardised diagnostic techniques fail to identify the organ where it originated, resulting in a poor prognosis and resistance to treatment. Recent advances in large-scale sequencing techniques have enabled the identification of mutational signatures specific to particular tumour subtypes, even from liquid biopsy samples such as blood. This breakthrough paves the way for the development of new cost-effective diagnostic strategies. This mini-review explores recent advancements in Machine Learning (ML) and its application to tumour classification methods for CUP patients, identifying its weaknesses and strengths when classifying the tumour type. In the era of multi-omics, integrating several sources of information (e.g., imaging, molecular biomarkers, and family history) requires important theoretical advancements: increasing the dimensionality of the problem can result in lowering the predictive accuracy and robustness when data is scarce. Here, we review and discuss different architectures and strategies for incorporating cutting-edge machine learning into CUP diagnosis, aiming to bridge the gap between theory and clinical practice.
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    Clinical features and sex hormone profile in male patients with frontal fibrosing alopecia: A multicenter retrospective study with 33 patients
    (2022) Doche, Isabella; Nico, Maechello; Gerlero, Paula; Rebeis, Mariana; Melo, Daniel; Tortelly, Violeta; Ramos, Paulo; Larrondo Gálvez, Jorge Felipe; Mardones, Felipe; González, Martha L.; Tosti, Antonella; Rivitti-Machado, Maria Cecília
    Frontal fibrosing alopecia (FFA) is considered as a variant of lichen planopilaris with an unclear pathogenesis. First described in postmenopausal women, FFA has recently been reported in young men and women.1, 2, 3, 4, 5 The recent worldwide incidence of this disease, mainly among women, raises the possibility of hormonal disruption by endogenous or exogenous factors. This multicenter retrospective study aimed to describe the clinical features and sex hormone profile of men with FFA and no previous history of sex hormone disorders using a chart and image review from 2019 to 2021. All subjects were asked to have their hormone profiles prepared. The study was approved by the Ethics Committee of the University of Sao Paulo, Brazil.

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