Browsing by Author "Herrera, Claudia"
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Item Proceso logístico productivo de un centro de sangre regional: modelamiento y análisis(2011) Baesler, Felipe; Martínez, Cristina; Yaksic, Eduardo; Herrera, ClaudiaBackground: The blood supply chain is a complex system that considers different interconnected elements that have to be synchronized correctly to satisfy in quality and quantity the final patient requirements. Aim: To determine the blood center maximum production capacity, as well as the determination of the necessary changes for a future production capacity expansion. Material and Methods: This work was developed in the Blood Center of Concepcion, Chile, operations management tools were applied to model it and to propose improvement alternatives for the production process. The use of simulation is highlighted, which permitted the replication of the center behavior and the evaluation of expansion alternatives. Results: It is possible to absorb a 100% increment in blood demand, without making major changes or investments in the production process. Also it was possible to determine the subsequent steps in terms of investments in equipment and human resources for a future expansion of the center coverage. Conclusions: The techniques used to model the production process of the blood center of Concepcion, Chile, allowed us to analyze how it operates, to detect "bottle necks", and to support the decision making process for a future expansion of its capacity (Rev Med Chile 2011; 139: 1150-1156).Item Theta and Alpha Oscillation Impairments in Autistic Spectrum Disorder Reflect Working Memory Deficit(2017) Larraín-Valenzuela, Josefina; Zamorano, Francisco; Soto-Icaza, Patricia; Carrasco, Ximena; Herrera, Claudia; Daiber, Francisca; Aboitiz, Francisco; Billeke, PabloA dysfunction in the excitatory–inhibitory (E/I) coordination in neuronal assembly has been proposed as a possible neurobiological mechanism of Autistic Spectrum Disorder (ASD). However, the potential impact of this mechanism in cognitive performance is not fully explored. Since the main consequence of E/I dysfunction is an impairment in oscillatory activity and its underlying cognitive computations, we assessed the electroencephalographic activity of ASD and typically developing (TD) subjects during a working-memory task. We found that ASD subjects committed more errors than TD subjects. Moreover, TD subjects demonstrated a parametric modulation in the power of alpha and theta band while ASD subjects did not demonstrate significant modulations. The preceding leads to significant differences between the groups in both the alpha power placed on the occipital cortex and the theta power placed on the left premotor and the right prefrontal cortex. The impaired theta modulation correlated with autistic symptoms. The results indicated that ASD may present an alteration in the recruitment of the oscillatory activity during working-memory, and this alteration could be related to the physiopathology of the disorder.