Browsing by Author "Harrop, James S."
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Publication A Systematic Review of Current Terminology for Conditions Preceding Degenerative Cervical Myelopathy: Evidence Synthesis to Inform an AO Spine Expert Opinion Statement(2025) Agrawal, Vinisha; Farhan Ali, Mohammed; Yasin, Froher; Ashraf, Daniyal; Brannigan, Jamie F. M.; Yurac, Ratko; Kumar, Vishal; Murphy, Rory; Tessitore, Enrico; Molliqaj, Granit; Dejaegher, Joost; Zamorano, Juan José; Wynne-Jones, Guy; Tripathi, Manjul; Anderson, David B.; Arbatin, Jose Joefrey F.; Kato, So; Romelean Jayapalan, Ronie; Dea, Nicolas; Harrop, James S.; Wilson, Jefferson; Kwon, Brian K.; Martin, Allan R.; Bednarik, Josef; Kotter, Mark R.; Davies, Benjamin M.; Mowforth, Oliver D.; Nouri. AriaStudy Design: Systematic review. Objectives: The pre-symptomatic state of Degenerative Cervical Myelopathy (DCM), wherein degenerative changes and spinal cord compression are seen without clinical findings, is poorly understood and inconsistently categorised. Clear identification may elucidate the temporality of DCM development. Therefore, a systematic assessment was undertaken of current terminology for pre-DCM states, with the objective of standardising definitions and informing an AO Spine expert position statement. Methods: Medline and Embase were searched for all studies on asymptomatic spinal compression or clinical findings preceding DCM, returning 3585 studies. After screening, 96 studies were included in the final analysis. The terminology used for pre-DCM states and their definitions were extracted, along with their frequencies or speciality/country of author in the literature. Results: Multiple terms were used to represent pre-DCM stages, including “asymptomatic” (86 studies), “non-myelopathic” (26 studies), “without myelopathy” (15 studies), “pre-symptomatic” (9 studies) and “sub-clinical” (7 studies). “asymptomatic” was associated with the greatest inconsistency. Some defined this as patients with radiological signs of spinal degeneration with/without spinal cord compression but no clinical signs of myelopathy, whereas others used the term synonymously with healthy controls. This inconsistency is particularly challenging in clinical studies in which DCM patients are compared to those with pre- DCM states and/or healthy volunteers. Conclusion: There is substantial inconsistency in the terms used to describe pre-DCM states. There is no clear relationship between the terms used and the country or speciality of the main author. Standardised definitions for these disease states should be agreed and used in future studies.Publication Mielopatía cervical degenerativa: una patología cada vez más frecuente y que requiere diagnóstico y manejo precoz(2022) Zamorano, Juan José; Yurac, Ratko; Matamala, José Manuel; Harrop, James S.; Davies, Benjamin M.; Nouri, Aria; Fehlings, Michael G.Degenerative cervical myelopathy (DCM) is the most common cause of spinal cord dysfunction in adults. Its prevalence is increasing as a result of population aging. The diagnosis of DCM is often delayed or overlooked, resulting in secondary neurologic morbidity. The natural course of DCM typically presents as a gradual neurological deterioration, with symptoms ranging from muscle weakness to complete paralysis, with variable degrees of sensory deficits and sphincter dysfunction. Magnetic resonance imaging (MRI) and electrophysiological studies allow the assessment of spinal cord function and its structural damage to determine treatment and clinical outcomes. All patients with signs and symptoms consistent with DCM should be referred to a spine surgeon for assessment and tailored treatment. Those patients with mild DCM can be managed non-operatively but require close monitoring and education about potentially alarming signs and symptoms. Surgery is not currently recommended for asymptomatic patients with evidence of spinal cord compression or cervical spinal stenosis on MRI, but they require a structured follow-up. Patients with moderate or severe DCM require surgical decompression to avoid further progression. The objective of this review is to raise awareness of degenerative cervical myelopathy and its increasing prevalence as well as to aid non-surgical healthcare workers for a timely diagnosis and management of this disabling condition.