Browsing by Author "Grossman, Nicole"

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    Efecto de las variantes de VKORC1 y CYP2C9 sobre la dosis de anticoagulantes orales en individuos chilenos
    (Sociedad Medica de Santiago, 2015) Benavides, Felipe; Grossman, Nicole; Poggi, Helena; Nieto, Elena; Bertrán, Antonio; Araos, Daniel; Vásquez, Marcos; Ibarra, Ignaz; Caceres, Felipe; Espinoza, Karena; Lagos, Marcela; Repetto, Gabriela
    BACKGROUND: The dose of oral anticoagulants (OAC) shows great variability among patients. Pharmacogenetic studies have shown that common variants in genes CYP2C9 (*2 and *3) and VKORC1 (-1639G>A) are associated with lower requirements of OAC. AIM: To study the association between average maintenance doses of oral anticoagulant therapy required to maintain a stable INR and CYP2C9 and VKORC1 gene variants in Chilean adults. MATERIAL AND METHODS: Prospective study of patients on anticoagulant treatment and with a stable international normalized ratio (INR) for prothrombin time for at least three months. Patients were classified as having high or low acenocoumarol or warfarin requirements. Peripheral blood DNA genotyping was performed by polymerase chain reaction and restriction fragment polymorphism or sequencing and electrophoresis. RESULTS: The study included 185 patients, 125 on acenocoumarol and 60 on warfarin. Patients with VKORC1-1639A allele were more likely to require lower doses of both drugs than patients with the G allele (Odds ratio [OR] for acenocoumarol 9.06, and OR for warfarin = 18.7). There was no association between CYP2C9*2 and*3 and acenocoumarol or warfarin requirements. CONCLUSIONS: There is an association between VKORC1-1639A variant and anticoagulant doses.
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    Trasplante de órganos, una mirada desde el judaísmo en el siglo XXI
    (Sociedad Medica de Santiago, 2012) Grossman, Nicole; Herrera, Javiera; Luco, Lorna
    Organ transplantation frequently constitutes a source of public concern. Dealing with such a complex medical problems requires a process of recognition of the different attitudes that social groups have toward organ transplantation attitudes which might vary accordingly to cultural and religious diversity. Judaism is the focus of this review. Our objective is to contribute to the knowledge that Chilean health professionals have about the Jewish point of view on organ transplantation. The supreme value of life is a premise of Judaism, so saving a life should precede the enforcement of certain Old Testament's prohibitions. However, it is difficult and misleading to attempt to define a unique point of view-even though there is an overwhelming majority who are in favor of organ donation-because different theological interpretations and recommendations are continuously in debate. We conclude that the mainstream Jewish position is not significantly different from the contemporary Western thought, even though a minority in Judaism is opposed to cadaveric organ donation.

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