Browsing by Author "Goset, Karen"

Now showing 1 - 2 of 2
  • Thumbnail Image
    Item
    Manejo actual de las metástasis vertebrales: un trabajo en equipo
    (2021) Silva, Álvaro; Bravo, Oscar; Salas, Claudio; Yurac, Ratko; Valencia, Javiera; Goset, Karen; Harbst, Hans; Córdova, Andrés
    La enfermedad metastásica vertebral es frecuente en los pacientes con cáncer avanzado, y conlleva a complicaciones inherentes a su progresión, como lo son la fractura patológica vertebral y la compresión neural metastásica. Se realizó una revisión de los aspectos terapéuticos actuales del manejo de la progresión y de las complicaciones de la enfermedad metastásica vertebral, enfatizando su enfrentamiento sistémico y personalizado. Nuestro objetivo principal es proporcionar información sobre el tratamiento actual de esta afección y la utilidad del manejo sistémico y multidisciplinario.
  • Thumbnail Image
    Item
    PREDICTIVE MODELS FOR PULMONARY FUNCTION CHANGES AFTER RADIOTHERAPY FOR BREAST CANCER AND LYMPHOMA
    (2012) Sánchez, Beatriz; Goset, Karen; Caviedes, Iván; Delgado, Iris; Córdova, Andrés
    Purpose: To propose multivariate predictive models for changes in pulmonary function tests (DPFTs) with respect to preradiotherapy (pre-RT) values in patients undergoing RT for breast cancer and lymphoma. Methods and Materials: A prospective study was designed to measure DPFTs of patients undergoing RT. Sixty-six patients were included. Spirometry, lung capacity (measured by helium dilution), and diffusing capacity of carbon monoxide tests were used to measure lung function. Two lung definitions were considered: paired lung vs. irradiated lung (IL). Correlation analysis of dosimetric parameters (mean lung dose and the percentage of lung volume receiving more than a threshold dose) and DPFTs was carried out to find the best dosimetric predictor. Chemotherapy, age, smoking, and the selected dose-volume parameter were considered as single and interaction terms in a multivariate analysis. Stability of results was checked by bootstrapping. Results: Both lung definitions proved to be similar. Modeling was carried out for IL. Acute and late damage showed the highest correlations with volumes irradiated above 20 Gy (maximum R2 = 0.28) and 40 Gy (maximum R2 = 0.21), respectively. RT alone induced a minor and transitory restrictive defect (p = 0.013). Doxorubicin-cyclophosphamide-paclitaxel (Taxol), when administered pre-RT, induced a late, large restrictive effect, independent of RT (p = 0.031). Bootstrap values confirmed the results. Conclusions: None of the dose-volume parameters was a perfect predictor of outcome. Thus, different predictor models for DPFTs were derived for the IL, which incorporated other nondosimetric parameters mainly through interaction terms. Late DPFTs seem to behave more serially than early ones. Large restrictive defects were demonstrated in patients pretreated with doxorubicin-cyclophosphamide-paclitaxel.

Implementado por OpenGeek Services