Browsing by Author "Giordano, Consuelo"

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    CLOVES syndrome: Treatment with oral Rapamycin. Report of two cases
    (2019) De Grazia, Renatta; Giordano, Consuelo; Cossio, Laura; Downey, Camila; Delucchi, Ángela; Kramer, Daniela
    Introduction: CLOVES syndrome is characterized by lipomatous overgrowth associated with vascular malforma tions, representing a diagnostic and a therapeutic challenge. Rapamycin, an mTOR inhibitor, has proved to be a good therapeutic option in some vascular anomalies. In this article, we report two ca ses of CLOVES syndrome with good response to oral rapamycin treatment. Objective: To report the outcome of two patients with CLOVES syndrome treated with oral rapamycin. Clinical cases: Case 1: A three-year-old female preschooler with CLOVES syndrome and history of repeated hospita lizations due to severe infections resulting from macrocystic lymphatic malformations and due to thrombotic episodes. The patient evolved with poor quality of life, multiple hospitalizations, surgical risk and progression of the lesions, therefore, oral rapamycin was indicated. After six months of treatment, clinical and radiological reduction in the size of the lipomatous and lymphatic masses, cutaneous lymphorrhea absence and a significant improvement of her quality of life were observed, without requiring new hospitalizations. Case 2: a ten-year-old female schooler with CLOVES syndro me, who developed scoliosis and deterioration of her motor skills, becoming wheelchair-dependent. Oral rapamycin was indicated, showing improvement in her physical capacity, independence and au tonomy, and absence of lymphorrhea after four months of treatment. Conclusion: We propose oral rapamycin for the treatment of patients with CLOVES syndrome who present with complications and deterioration in the quality of life as a result of the disease.
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    Demodicosis facial con respuesta exitosa a ivermectina tópica Facial demodicosis with successful response to topical ivermectin
    (2020) Pérez-Wilson, Jaime; Giordano, Consuelo; García, Viviana; Castro, Alex
    Demodecidosis o demodicosis son los términos utilizados para referirse a las enfermedades cuta ́neas causadas por los acaros foliculares del genero Demodex, Demodex folliculorum y Demodex brevis. La demodicosis es una enfermedad cuta ́nea crónica caracterizada por papulas y maculas eritematosas pruriginosas que afecta principalmente a la cara. Los Demodex son los ectoparasitos más frecuentes encontrados en la piel del ser humano; se considera que forman parte de la flora comensal de la unidad piloseba ́cea, pero tambie ́n se han visto implicados como agentes causales de diversas dermatosis, que se revisarán más adelante.
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    Multifocal capillary malformation with segmental distribution and central atrophy: A case in a 12-year-old girl
    (2021) Rollan, María Paz; Fajre, Ximena; Giordano, Consuelo; Whittle, Carolina; Castro M., Álex
    We present a 12-year-old girl with multiple geographic capillary malformations in a segmental distribution over the left trunk and arm that were present at birth and evolved over years with ulceration, atrophy, and subsequent scarring. Our case is clinically consistent with the recently described entity “multifocal capillary malformation with segmental distribution and central atrophy.” To our knowledge, our patient is the oldest reported to date

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