Browsing by Author "Fajre, Ximena"
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Item Lamotrigine-induced Sweet syndrome: Possible new drug association(2020) Neely, Gabriel; Fajre, Ximena; Cabrera, Raúl; Castro, AlexItem Multifocal capillary malformation with segmental distribution and central atrophy: A case in a 12-year-old girl(2021) Rollan, María Paz; Fajre, Ximena; Giordano, Consuelo; Whittle, Carolina; Castro M., ÁlexWe present a 12-year-old girl with multiple geographic capillary malformations in a segmental distribution over the left trunk and arm that were present at birth and evolved over years with ulceration, atrophy, and subsequent scarring. Our case is clinically consistent with the recently described entity “multifocal capillary malformation with segmental distribution and central atrophy.” To our knowledge, our patient is the oldest reported to dateItem New Use of Rapamycin Stent in Non-Responding Facial Lymphatic Malformation(Biomedical Journal of Scientific, 2019) Vargas, Patricio; Whittle, Carolina; Recule, Francisca; Fajre, XimenaIntroduction: Vascular anomalies represent a diagnostic and therapeutic difficulty. A lymphatic malformation (LM) corresponds to a low-flow vascular malformation. Sclerotherapy is the preferred treatment. Recently, angiogenesis inhibitors such as Rapamycin have been used with promising results. Case Report: A pediatric patient presented with a large facial LM and poor response to Sildenafil and sclerotherapy. After a persistent enlargement of the lesion, with painful ocular occlusion a new sclerotherapy was performed obtaining partial improvement. As a rescue treatment an IRS was installed. The patient achieved a rapid and evident response, with better ocular aperture and pain control. Discussion: LM correspond to vasculogenesis disorders with persistent growth over time. They can present high morbidity. The complications in the facial area are infection, hemorrhage, exophthalmos, and amblyopia. Rapamycin is a potent angiogenesis inhibitor. Rapamycin stents have been safely used in cardiology. They provide local concentration with less adverse effects. There are no reports on their use in lymphatic malformation. The patient had a favorable and persistent response. Conclusion: IRS should be considered as a therapeutic alternative in severe nonresponding lymphatic malformation. The necessity of a multidisciplinary approach is fundamentalItem Posible asociación autoinmune entre síndrome de Laugier-Hunziker y síndrome de Sjögren: reporte de un caso y revisión de la literatura(Sociedad Medica de Santiago, 2016) Fajre, Ximena; Aspillaga, Maria; McNab, Maria; Navarrete, Jorge; Sanhueza, Veronica; Benedetto, JuanaLaugier-Hunziker syndrome is a rare benign idiopathic condition characterized by acquired macular pigmentation of lips and buccal mucosa, often accompanied with melanonychia. The main concern with this condition is to rule out other differential diagnosis with systemic repercussions and similar hyperpigmentation patterns, such as Peutz-Jeghers syndrome, adrenal insufficiency and melanoma. We report a 58-year-old female with a 20-year history of Sjögren’s syndrome, presenting with melanonychia and hyperpigmentation in the buccal mucosa. She had no relevant medication history and is a non-smoker. The patient denied any other symptoms. The histopathology confirmed the diagnosis of Laugier-Hunziker syndrome.Item Subungual Exostosis: High-Resolution Ultrasound Findings(2019) Whittle, Carolina; Aguirre, Javiera; Catalán, Verónica; Fajre, XimenaSubungual exostosis is a rare solitary benign osteocartilaginous tumor that arises from the tuft of the distal phalanx beneath the nail. Because of its multiple clinical presentations, it is commonly underdiagnosed, resulting in delayed diagnosis and inadequate treatment. This report provides results from a 6-year retrospective study. All patients with a sonographic diagnosis of subungual exostosis confirmed surgically were selected. The data came from a series of 19 patient cases. Only 15.7% were clinically suspected. The median age was 21 years, and 63% were females. The sonographic findings were nail dystrophy, distal onycholysis, abnormal nail incurvation, subungual space enlargement, and the presence of hyperechogenic subungual image with acoustic shadowing that continued until the phalanx surface. Sonography provides an excellent diagnostic method for subungual exostosis, with findings that are pathognomonic.