Browsing by Author "Donohoe, Gary"
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Publication Correction: Obesity and brain structure in schizophrenia - ENIGMA study in 3021 individuals(2022) McWhinney, Sean; Brosch, Katharina; Calhoun, Vince; Crespo, Benedicto; Crossley, Nicolas; Dannlowski, Udo; Dickie, Erin; Dietze, Lorielle; Donohoe, Gary; Du Plessis, Stefan; Ehrlich, Stefan; Emsley, Robin; Furstova, Petra; Glahn, David; Gonzalez, Alfonso; Grotegerd, Dominik; Holleran, Laurena; Kircher, Tilo; Knytl, Pavel; Kolenic, Marian; Lencer, Rebekka; Nenadić, Igor; Opel, Nils; Pfarr, Julia; Rodrigue, Amanda; Rootes, Kelly; Ross, Alex; Sim, Kang; Škoch, Antonín; Spaniel, Filip; Stein, Frederike; Švancer, Patrik; Tordesillas, Diana; Undurraga, Juan; Vázquez, Javier; Voineskos, Aristotle; Walton, Esther; Weickert, Thomas; Weickert, Cynthia; Thompson, Paul; M Van Erp, Theo; Turner, Jessica; Hajek, TomasCorrección de: Molecular Psychiatry https://doi-org.udd.idm.oclc.org/10.1038/s41380-022-01616-5 , publicado en línea el 14 de junio de 2022 El nombre de uno de los coautores (Javier Vázquez-Bourgon) había sido escrito incorrectamente en el pasado, lo que ya ha sido corregido. The article “Obesity and brain structure in schizophrenia – ENIGMA study in 3021 individuals”, written by Sean R. McWhinney, Katharina Brosch, Vince D. Calhoun, Benedicto Crespo-Facorro, Nicolas A. Crossley, Udo Dannlowski, Erin Dickie, Lorielle M. F. Dietze, Gary Donohoe, Stefan Plessis, Stefan Ehrlich, Robin Emsley, Petra Furstova, David C. Glahn, Alfonso Gonzalez- Valderrama, Dominik Grotegerd, Laurena Holleran, Tilo T. J. Kircher, Pavel Knytl, Marian Kolenic, Rebekka Lencer, Igor Nenadić, Nils Opel, JuliaKatharina Pfarr, Amanda L. Rodrigue, Kelly Rootes-Murdy, Alex J. Ross, Kang Sim, Antonín Škoch, Filip Spaniel, Frederike Stein, Patrik Švancer, Diana Tordesillas-Gutiérrez, Juan Undurraga, Javier Váquez-Bourgon, Aristotle Voineskos, Esther Walton, Thomas W. Weickert, Cynthia Shannon Weickert, Paul M. Thompson, Theo G. M. Erp, Jessica A. Turner, Tomas Hajek, was originally published electronically on the publisher’s internet portal on 14 June 2022 without open access. With the author(s)’ decision to opt for Open Choice the copyright of the article changed on 20 May 2022 to © The Author(s) 2022 and the article is forthwith distributed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/ licenses/by/4.0/.Item Effects of copy number variations on brain structure and risk for psychiatric illness: Large-scale studies from the ENIGMA working groups on CNVs(2022) Sønderby, Ida; Ching, Christopher; Thomopoulos, Sophia; Van der Meer, Dennis; Sun, Daqiang; Villalon, Julio; Agartz, Ingrid; Amunts, Katrin; Arango, Celso; Armstrong, Nicola; Ayesa, Rosa; Bakker, Geor; Bassett, Anne; Boomsma, Dorret; Bülow, Robin; Butcher, Nancy; Calhoun, Vince; Caspers, Svenja; Chow, Eva; Cichon, Sven; Ciufolini, Simone; Craig, Michael; Crespo, Benedicto; Cunningham, Adam; Dale, Ander; Dazzan, Paola; De Zubicaray, Greig; Djurovic, Srdjan; Doherty, Joanne; Donohoe, Gary; Draganski, Bogdan; Durdle, Courtney; Ehrlich, Stefan; Emanuel, Beverly; Espeseth, Thomas; Fisher, Simon; Ge, Tian; Glahn, David; Grabe, Hans; Gur, RaquelThe Enhancing NeuroImaging Genetics through Meta-Analysis copy number variant (ENIGMA-CNV) and 22q11.2 Deletion Syndrome Working Groups (22q-ENIGMA WGs) were created to gain insight into the involvement of genetic factors in human brain development and related cognitive, psychiatric and behavioral manifestations. To that end, the ENIGMA-CNV WG has collated CNV and magnetic resonance imaging (MRI) data from ~49,000 individuals across 38 global research sites, yielding one of the largest studies to date on the effects of CNVs on brain structures in the general population. The 22q-ENIGMA WG includes 12 international research centers that assessed over 533 individuals with a confirmed 22q11.2 deletion syndrome, 40 with 22q11.2 duplications, and 333 typically developing controls, creating the largest-ever 22q11.2 CNV neuroimaging data set. In this review, we outline the ENIGMA infrastructure and procedures for multi-site analysis of CNVs and MRI data. So far, ENIGMA has identified effects of the 22q11.2, 16p11.2 distal, 15q11.2, and 1q21.1 distal CNVs on subcortical and cortical brain structures. Each CNV is associated with differences in cognitive, neurodevelopmental and neuropsychiatric traits, with characteristic patterns of brain structural abnormalities. Evidence of gene-dosage effects on distinct brain regions also emerged, providing further insight into genotype-phenotype relationships. Taken together, these results offer a more comprehensive picture of molecular mechanisms involved in typical and atypical brain development. This "genotype-first" approach also contributes to our understanding of the etiopathogenesis of brain disorders. Finally, we outline future directions to better understand effects of CNVs on brain structure and behavior.Publication Obesity and brain structure in schizophrenia - ENIGMA study in 3021 individuals(2022) McWhinney, Sean; Brosch, Katharina; Calhoun, Vince; Crespo, Benedicto; Crossley, Nicolas; Dannlowski, Udo; Dickie, Erin; Dietze, Lorielle; Donohoe, Gary; Du Plessis, Stefan; Ehrlich, Stefan; Emsley, Robin; Furstova. Petra; Glahn, David; Gonzalez, Alfonso; Grotegerd, Dominik; Nenadić , Igor; Ope, Nils; Pfarr, Julia; Rodrigue, Amanda; Stein, Frederike; Švance, Patrik; Tordesillas, Diana; Undurraga, Juan; Vázquez-Bourgon, Javier; Voineskos, Aristotle; Walton, Esther; Weickert, Thomas; Shannon, Cynthia; Thompson, Paul; Van Erp, Theo; Turner, Jessica; Hajek, TomasSchizophrenia is frequently associated with obesity, which is linked with neurostructural alterations. Yet, we do not understand how the brain correlates of obesity map onto the brain changes in schizophrenia. We obtained MRI-derived brain cortical and subcortical measures and body mass index (BMI) from 1260 individuals with schizophrenia and 1761 controls from 12 independent research sites within the ENIGMA-Schizophrenia Working Group. We jointly modeled the statistical effects of schizophrenia and BMI using mixed effects. BMI was additively associated with structure of many of the same brain regions as schizophrenia, but the cortical and subcortical alterations in schizophrenia were more widespread and pronounced. Both BMI and schizophrenia were primarily associated with changes in cortical thickness, with fewer correlates in surface area. While, BMI was negatively associated with cortical thickness, the significant associations between BMI and surface area or subcortical volumes were positive. Lastly, the brain correlates of obesity were replicated among large studies and closely resembled neurostructural changes in major depressive disorders. We confirmed widespread associations between BMI and brain structure in individuals with schizophrenia. People with both obesity and schizophrenia showed more pronounced brain alterations than people with only one of these conditions. Obesity appears to be a relevant factor which could account for heterogeneity of brain imaging findings and for differences in brain imaging outcomes among people with schizophrenia.