Browsing by Author "Ciampi, Ethel"

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    Frontoparietal connectivity correlates with working memory performance in multiple sclerosis
    (2020) Figueroa-Vargas, Alejandra; Cárcamo, Claudia; Henríquez-Ch, Rodrigo; Zamorano, Francisco; Ciampi, Ethel; Uribe-San-Martin, Reinaldo; Vásquez, Macarena; Aboitiz, Francisco; Billeke, Pablo
    Working Memory (WM) impairment is the most common cognitive deficit of patients with Multiple Sclerosis (MS). However, evidence of its neurobiological mechanisms is scarce. Here we recorded electroencephalographic activity of twenty patients with relapsing-remitting MS and minimal cognitive deficit, and 20 healthy control (HC) subjects while they solved a WM task. In spite of similar performance, the HC group demonstrated both a correlation between temporoparietal theta activity and memory load, and a correlation between medial frontal theta activity and successful memory performances. MS patients did not show theses correlations leading significant differences between groups. Moreover, cortical connectivity analyses using granger causality and phase-amplitude coupling between theta and gamma revealed that HC group, but not MS group, presented a load-modulated progression of the frontal-to-parietal connectivity. This connectivity correlated with working memory capacity in MS groups. This early alterations in the oscillatory dynamics underlaying working memory could be useful for plan therapeutic interventions.
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    White matter volume and microstructural integrity are associated with fatigue in relapsing multiple sclerosis
    (2025) Figueroa-Vargas, Alejandra; Navarrete-Caro, Sebastián; Cárcamo, Claudia; Ciampi, Ethel; Vásquez-Torres, Macarena; Soler, Bernardita; Montalba, Cristian; Iriarte-Carter, Matías; Martínez-Molina, María Paz; Carvajal-Paredes, Patricio; Ayala-Ochoa, Mariana; Márquez-Rodríguez, Víctor; Figueroa-Taiba, Paulo; Díaz-Díaz, Marcela; Herrero, Joaquín; Henríquez-Ch., Rodrigo; Stecher, Ximena; Manterola, Carla; Zamorano, Francisco; Guevara, Pamela; Aboitiz, Francisco; Billeke, Pablo
    Multiple sclerosis (MS) is a prevalent neurological disorder marked by inflammation and demyelination, with fatigue being one of the most reported and debilitating symptoms. While fatigue occurs across various neurological conditions and even in healthy individuals, the specific mechanisms contributing to fatigue in each context remain unclear. In this study, we conducted a cross-sectional analysis involving 32 people with relapsing MS (PwRMS) and 29 healthy controls who reported fatigue. Participants underwent MRI scans, including T1-weighted and diffusion-weighted imaging. Additionally, the Modified Fatigue Impact Scale was utilized. We employed Bayesian LASSO and Spike-and-Slab LASSO regression models to investigate the hypothesis that fatigue correlates differently with brain structures in PwRMS. Our findings revealed brain regions associated with general and cognitive fatigue. In particular, reduced white matter volume and compromised microstructural integrity in specific areas—such as the cingulate gyrus, inferior frontal gyrus, and the banks of the superior temporal sulcus—showed significant associations with fatigue scores in PwRMS. These results suggest that alterations in specific brain regions may play a critical role in the clinical manifestation of fatigue in MS. Understanding these insights could help differentiate general mechanisms of fatigue from those affecting people with relapsing MS, which may guide future therapeutic strategies.

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