Browsing by Author "Castaner, Olga"

Now showing 1 - 2 of 2
  • Thumbnail Image
    Publication
    Cardiovascular risk factors and the allostatic interoceptive network in dementia
    (2025) Hazelton, Jessica; Migeot, Joaquín; Gonzalez, Raul; Altschuler, Florencia; Duran, Claudia; Wen, Olivia; Galván, Dante; Barttfeld, Pablo; Medel , Vicente; González, Cecilia; Castro, Ana; Hernández, Hernán; Gonzalez, Carolina; Castaner, Olga; Hu, Kun; Li, Peng; Maria Isabel Behrens; Behrens, Maria Isabel; Bruno, Martin; Cardona, Juan; Custodio, Nilton; Santamaria, Hernando; Garcia, Adolfo; Godoy, Maria; Avila, José; Maito, Marce; Matallana, Diana; Miller, Bruce; Lopera, Francisco; Okada , Maira; Pina, Stefanie; Possin, Katherine; France, Elisa de Paula; Reyes, Pablo; Slachevsky Chonchol, Andrea; Sosa, Ana; Takada, Leonel; Yokoyama, Jennifer; Ibanez, Agustin
    Aims: Cardiovascular risk factors, such diabetes, hypertension, blood pressure, obesity, and smoking, are linked with allostatic-interoception-the continuous monitoring of internal bodily states in anticipation of environmental demands. These risk factors are associated with dementia risk. How these factors affect brain networks vulnerable to neurodegeneration and involved in allostatic-interoception, such as the Allostatic-Interoceptive Network (AIN), is unknown. We investigated the relationship between cardiovascular risk and AIN structure and function in frontotemporal lobar degeneration (FTLD) and Alzheimer's disease (AD). Methods and results: We recruited 1501 participants (304 with FTLD, 512 with AD, and 685 healthy controls) from the Multi-Partner Consortium to Expand Dementia Research in Latin America (ReDLat). A cardiovascular risk score was calculated based on: age, sex, diabetes, hypertension, systolic blood pressure, body mass index, and smoking status. Cardiovascular risk was associated with grey matter integrity and functional connectivity in age- and sex-matched patient-control groups focusing on predefined regions of interest within the AIN. Higher cardiovascular risk was associated with reduced structural integrity and functional connectivity within the AIN in both FTLD and AD. FTLD patients showed more extensive structural and functional connectivity disruptions throughout the AIN. In AD patients, structural reductions in the AIN were prominent, with functional connectivity restricted to the hippocampus, parahippocampal gyrus, and orbitofrontal regions. Conclusion: Cardiovascular risk factors appear to adversely impact the AIN structure and function, with disease-specific patterns of vulnerability. Results underscore the importance of integrating cardiovascular health into models of neurodegenerative disease and managing cardiovascular health to support brain integrity in dementia.
  • Thumbnail Image
    Publication
    Dementia prevention requires moving beyond individual choice: the costs of effort and time intersect with social determinants of health
    (2025) Migeot, Joaquín; Araya, Daniel; Montecinos, Matias; Baez, Sandra; Behrens, Maria Isabel; Castaner, Olga; Cruzat, Josephine; Delgado, Carolina; De Jong- Bambagioni, David; Duran, Claudia; Durón, Dafne; Evans, Tavia; Gonzalez, Raul; Gutiérrez, Myriam; Hayden, Katheen; Hernandez, Hernan; Ibañez, Agustin; Legaz, Agustina; Miller, Johnny; Ma iulskyt, Sonata; Putthinun, Pongpat; Santamaría, Hernando; Slachevsky Chonchol, Andrea; Trépel, Dominic
    Social determinants of health strongly influence modifiable risk factors for dementia, yet prevention frameworks list only individual-level behaviours and conditions, overlooking the impact of social and environmental factors on the risk of dementia. In this perspective, we introduce the concept of non-monetary costs as a central mechanism through which social determinants shape modifiable risk factors by influencing individuals' ability to adopt healthy behaviours. Drawing from economic theory, we define non-monetary costs as the time and metabolic cost, perceived by individuals as physical and cognitive effort, required to engage in healthy behaviours. Under adverse social determinants of health, individuals effectively lack choice, as the non-monetary costs required to engage in healthy behaviours become prohibitively high. We propose a framework that links social determinants of health adversity to increased dementia risk through non-monetary costs. We apply this framework to each of the fourteen modifiable risk factors for dementia identified by the Lancet Commission, demonstrating how these costs systematically elevate risk in populations facing social adversity. Finally, we explore the implications of incorporating non-monetary cost assessments across research, interventions, clinical care, and public policy. We propose that quantifying and addressing these costs is essential for designing equitable, scalable, and contextually grounded strategies for dementia prevention across socially diverse populations.

Implementado por OpenGeek Services