Browsing by Author "Bedregal, Paula"
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Item Duration of untreated psychosis and acute remission of negative symptoms in a South American first-episode psychosis cohort.(Wiley Publishing Asia Pty Ltd., 2015) González-Valderrama, Alfonso; Castañeda, Carmen Paz; Mena, Cristián; Undurraga, Juan; Mondaca, Pilar; Yáñez, Matías; Bedregal, Paula; Nachar, RubénAIM: To determine the association between duration of untreated psychosis (DUP) and symptoms remission in a hospitalized first-episode psychosis cohort. METHODS: Inpatients with a first-episode non-affective psychosis were recruited. Subjects were divided into two groups of long and short DUP using a 3-month cut-off point, and this was related to remission at 10 weeks of treatment. Multivariate analyses were performed. RESULTS: Fifty-five inpatients were included. There were no differences in remission rates of positive symptoms. Up to 76.5% of the patients with a short DUP (<3 months) achieved remission of negative symptoms versus 31.6% in the DUP ≥ 3 months group (P = 0.003). After controlling for relevant factors, patients with a shorter DUP were still three times more likely to achieve negative symptoms remission (HR: 3.04, 95% CI 1.2-7.5). CONCLUSIONS: DUP is a prognostic factor that should be considered at an early stage to identify a 'high risk' subgroup of persistent negative symptoms.Publication Impacts of a Large-Scale Parenting Program: Experimental Evidence from Chile(2024) Carneiro, Pedro; Galasso, Emanuela; Lopez, Italo; Bedregal, Paula; Cordero. MiguelThis paper presents results from a large-scale experimental evaluation of the impacts on parents and children of a national parenting program in Chile. The program is low cost: it lasts only for six to eight weeks, and it is administered to groups (of 8 to 12 parents) rather than individuals. It is implemented by the national health system, taking advantage of its existing physical infrastructure, and the deep staff knowledge about the constraints faced by parents and children in each location. We find that children whose parents are offered the opportunity to participate in this program experience increases in their vocabulary and socio-emotional development scores of 0.1 standard deviations (SD), which are mirrored by improvements in parenting behaviors and parenting beliefs of the same magnitude. These impacts are observed almost three years after the intervention ends, far outlasting its duration.