DSpace Repository :: Browsing by Author "Aguilera, Viviana"

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Nitric Oxide Mediated Dexketoprofen Antinociception
(2020) Noriega, Viviana; Miranda, Hugo; Sierralta, Fernando; Sotomayor, Ramón; Prieto, Juan; Aguilera, Viviana
Nonsteroidal anti-inflammatory drugs (NSAIDs) are often used in the treatment of pain by their analgesic, anti-inflammatory and antipyretic properties. NSAIDs act via inhibition of cyclooxygenase enzymes, COX-1, COX-2 and COX-3. In this study, the antinociceptive activity of the dextrorotatory enantiomers of S (+) configuration of ketoprofen, denominate, dexketoprofen (DEX), was evaluated, before and after the pretreatment of mice with N( )-nitro-L-arginine methyl ester (L-NAME), in two models of pain. One model of tonic pain, the tail flick (TF) assay and in a second model of phasic pain, the acetic acid writhing test (WT). (DEX) administration produced a dose-dependent antinociceptive effect in both murine assays, but with different potency. The dose that produced 50 % of maximum possible effect (ED of antinociception of the WT was 3.87-fold more potent than TF. The pretreatment of mice with 1, 3 or 10 mg/kg, i.p of L-NAME produced a significant decrease of the antinociceptive effect of DEX, reflected with an important increase of ED in both assays. In conclusion, the results the application of DEX produced antinociception in the WT and TF models and in this effect the activation of NO pathway plays an important role.