Browsing by Author "Adachi, Javier A"
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Item Failure of High-Dose Daptomycin for Bacteremia Caused by Daptomycin-Susceptible Enterococcus faecium Harboring LiaSR Substitutions(2014) Munita, José; Mishra, Nagendra N.; Alvarez, Danya; Tran, Truc T; Diaz, Lorena; Panesso, Diana; Reyes, Jinnethe; Murray, Barbara E; Adachi, Javier A; Bayer, Arnold S; Arias, Cesar AHigh-dose daptomycin (DAP) therapy failed in a neutropenic patient with bloodstream infection caused by a DAP-susceptible Enterococcus faecium (minimum inhibitory concentration, 3 µg/mL) harboring genetic changes associated with DAP resistance, with persistent bacteremia and selection of additional resistances. Daptomycin monotherapy should be used cautiously against DAP-susceptible E. faecium strains with minimum inhibitory concentrations >2 µg/mL.