Gestational hypothyroxinemia causes an inflammatory environment at maternal-fetal tissues and fetal brain with impaired hippocampal dendritic spine maturation in the offspring

González, Enrique; Rangel, Andreina; Opazo, María; Espinoza, Sebastián; Elgueta, Daniela; Cancino, Gonzalo; Mery, Elena; Ardiles, Álvaro; Duarte, Luisa; Soto, Jorge; Carreño, Leandro; Simon, Felipe; Bueno, Susan; González, Pablo; Kalergis, Alexis

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Gestational hypothyroxinemia causes an inflammatory environment at maternal-fetal tissues and fetal brain with impaired hippocampal dendritic spine maturation in the offspring

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Gestational hypothyroxinemia causes an inflammatory environment at maternal-fetal tissues.pdf (5.87 MB)

Date

2025

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Article

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Artículos Medicina y Ciencias de la Salud

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https://doi.org/10.1038/s41598-025-26206-7

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https://hdl.handle.net/11447/11088

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Abstract

Gestational hypothyroxinemia (HTX) is associated with cognitive impairments and autism traits in offspring. However, the underlying mechanisms remain unclear. Prenatal inflammation impairs cortical de...

Citation

González-Madrid E, Rangel-Ramírez MA, Opazo MC, Espinoza SA, Elgueta D, Cancino GI, Mery E, Ardiles ÁO, Duarte LF, Soto JA, Carreño LJ, Simon F, Bueno SM, González PA, Kalergis AM, Riedel CA. Gestational hypothyroxinemia causes an inflammatory environment at maternal-fetal tissues and fetal brain with impaired hippocampal dendritic spine maturation in the offspring. Sci Rep. 2025 Nov 26;15(1):42160. doi: 10.1038/s41598-025-26206-7

Keywords

Cytokines , Embryonic neurodevelopment , Gestational hypothyroxinemia , Hippocampal dendritic spines , Maternal-fetal interface , Microglia , Prenatal inflammation

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