Utility of Transbronchial Lung Cryobiopsy in Non-Interstitial Diseases

Simple item page
dc.contributor.authorSánchez, Olivia
dc.contributor.authorMartínez, Dina
dc.contributor.authorFernández‐Bussy, Sebastián
dc.contributor.authorLópez, Berenice
dc.contributor.authorPerea, Carolina
dc.contributor.authorRivera, Rosa
dc.contributor.authorLuna, Cesar
dc.contributor.authorMartínez, José
dc.contributor.authorFlores, Luis
dc.contributor.authorSantillán, Patricio
dc.contributor.authorReyes, Gustavo
dc.date.accessioned2018-01-22T15:01:44Z
dc.date.available2018-01-22T15:01:44Z
dc.date.issued2017
dc.description.abstractBACKGROUND: Transbronchial lung cryobiopsy (TLCB), performed with a flexible cryoprobe, is an interventional pulmonology procedure that has proved its diagnostic value for interstitial pulmonary disease. However, it has not been explored extensively as a diagnostic tool for patients with noninterstitial lung pathology, including infectious and malignant diseases. OBJECTIVE: To evaluate the diagnostic yield and safety of an interventional pulmonology approach that integrates TLCB and bronchoalveolar lavage (BAL) for the diagnosis of non-interstitial pulmonary disease. METHODS: TLCB and BAL were performed under general anesthesia through the same bronchoscopic access on 103 adult patients (including immunocompromised HIV+ individuals) with clinical/radiological evidence of non-interstitial lung disease admitted to the Interventional Pulmonology Service between May 2015 and April 2016. Samples obtained were sent to pathology and microbiology laboratories for standard diagnostic analysis. RESULTS: Samples of TLCB allowed the diagnosis of 75.7% of patients, while 39.8% were diagnosed from BAL. The global diagnostic yield from the dual sampling was 92.2%. TLCB allowed the diagnosis of 94.7% of cancer cases and 60.0% of infectious cases, while BAL samples identified 77.5% of infectious cases and 21.2% of malignant lesions. The incidence of complications was 4.9% with full recovery in all cases. CONCLUSIONS: Simultaneous TLCB and BAL constitute a safe and useful diagnostic procedure for non-interstitial pulmonary disease, with a global diagnostic yield of 92.2%. Complementary advantages of samples obtained by each technique result in a robust diagnostic strategy for infectious and malignant disease in adults, including HIV+ individuals.
dc.format.extent8
dc.identifier.citationSánchez-Cabral O, Martínez-Mendoza D, Fernandez-Bussy S, López-González B, Perea-Talamantes C, Rivera-Rosales RM, Luna-Rivero C, Martínez-Orozco JA, Flores-Suárez LF, Santillán-Doherty P, Reyes-Terán G. Utility of Transbronchial Lung Cryobiopsy in Non-Interstitial Diseases. Respiration. 2017;94(3):285-292. doi: 10.1159/000478786.
dc.identifier.urihttp://hdl.handle.net/11447/1931
dc.identifier.urihttp://dx.doi.org/10.1159/000478786
dc.language.isoen_US
dc.publisherKarger
dc.sourceRespiration
dc.sourceVersión Publicada
dc.subjectCryobiopsy
dc.subjectDiagnosis
dc.subjectInterventional pulmonology
dc.subjectLung cancer
dc.titleUtility of Transbronchial Lung Cryobiopsy in Non-Interstitial Diseases
dc.typeArtículo

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Utility of Transbronchial Lung Cryobiopsy in Non-Interstitial Diseases.pdf
Size:
326.39 KB
Format:
Adobe Portable Document Format
Description:
Texto completo restringido
Download

Collections

Artículos Medicina y Ciencias de la Salud

Implementado por OpenGeek Services