Brain state-dependent recruitment of high-frequency oscillations in the human hippocampus

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dc.contributor.authorBilleke, Pablo
dc.contributor.authorOssandón, Tomás
dc.contributor.authorStockle, Marcelo
dc.contributor.authorPerrone-Bertolotti, Marcela
dc.contributor.authorKahane, Philippe
dc.contributor.authorLachaux, Jean-Philippe
dc.contributor.authorFuentealba, Pablo
dc.date.accessioned2017-11-09T21:08:21Z
dc.date.available2017-11-09T21:08:21Z
dc.date.issued01/09/2017
dc.description.abstractRipples are high-frequency bouts of coordinated hippocampal activity believed to be crucial for information transfer and memory formation. We used intracortical macro electrodes to record neural activity in the human hippocampus of awake subjects undergoing surgical treatment for refractory epilepsy and distinguished two populations of ripple episodes based on their frequency spectrum. The phase-coupling of one population, slow ripples (90-110 Hz), to cortical delta oscillations was differentially modulated by cognitive task; whereas the second population, fast ripples (130-170 Hz), was not seemingly correlated to local neural activity. Furthermore, as cognitive tasks changed, the ongoing coordination of neural activity associated to slow ripples progressively augmented along the parahippocampal axis. Thus, during resting states, slow ripples were coordinated in restricted hippocampal territories; whereas during active states, such as attentionally-demanding tasks, high frequency activity emerged across the hippocampus and parehippocampal cortex, that was synchronized with slow ripples, consistent with ripples supporting information transfer and coupling anatomically distant regions. Hence, our results provide further evidence of neural diversity in hippocampal high-frequency oscillations and their association to cognitive processing in humans. (C) 2017 Elsevier Ltd. All rights reserved.
dc.format.extent12 p.
dc.identifier.citationBilleke P, Ossandon T, Stockle M, Perrone-Bertolotti M, Kahane P, Lachaux JP, Fuentealba P. Brain state-dependent recruitment of high-frequency oscillations in the human hippocampus. Cortex. 2017 Sep;94:87-99.
dc.identifier.urihttp://hdl.handle.net/11447/1738
dc.identifier.urihttp://dx.doi.org/10.1016/j.cortex.2017.06.002
dc.language.isoen_US
dc.subjectIntracortical EEG
dc.subjectHippocampus
dc.subjectRipples
dc.titleBrain state-dependent recruitment of high-frequency oscillations in the human hippocampus
dc.typeArtículo

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