Microbial disruption indices to detect colonization with multidrug-resistant organisms.

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dc.contributor.authorAraos, Rafael
dc.contributor.authorMontgomery, Veronica
dc.contributor.authorUgalde, Juan
dc.contributor.authorSnyder, Graham
dc.contributor.authorD’Agata, Erika
dc.date.accessioned2018-01-15T12:29:23Z
dc.date.available2018-01-15T12:29:23Z
dc.date.issued2017
dc.description.abstractTo characterize the microbial disruption indices of hospitalized patients to predict colonization with multidrug-resistant organisms (MDROs). A cross-sectional survey of the fecal microbiome was conducted in a tertiary referral, acute-care hospital in Boston, Massachusetts. The study population consisted of adult patients hospitalized in general medical/surgical wards. Rectal swabs were obtained from patients within 48 hours of hospital admission and screened for MDRO colonization using conventional culture techniques. The V4 region of the 16S rRNA gene was sequenced to assess the fecal microbiome. Microbial diversity and composition, as well as the functional potential of the microbial communities present in fecal samples, were compared between patients with and without MDRO colonization. A total of 44 patients were included in the study, of whom 11 (25%) were colonized with at least 1 MDRO. Reduced microbial diversity and high abundance of metabolic pathways associated with multidrug-resistance mechanisms characterized the fecal microbiome of patients colonized with MDRO at hospital admission. Our data suggest that microbial disruption indices may be key to predicting MDRO colonization and could provide novel infection control approaches.
dc.format.extent7
dc.identifier.citationAraos R, Montgomery V, Ugalde JA, Snyder GM, D'Agata EMC. Microbial Disruption Indices to Detect Colonization With Multidrug-Resistant Organisms. Infect Control Hosp Epidemiol. 2017 Nov;38(11):1312-1318.
dc.identifier.urihttp://hdl.handle.net/11447/1891
dc.identifier.urihttp://dx.doi.org/10.1017/ice.2017.190
dc.language.isoen_US
dc.publisherCambridge University Press
dc.subjectMicrobial Disruption
dc.subjecthospitalized patients
dc.subjectmultidrug-resistant organisms (MDROs) colonization
dc.titleMicrobial disruption indices to detect colonization with multidrug-resistant organisms.
dc.typeArtículo

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