Factores de riesgo socio-demográficos del síndrome cardiopulmonar por hantavirus
Date
2019
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Article
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5 p.
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Abstract
Background: Hantavirus cardiopulmonary syndrome (HCPS) is caused by new world hantaviruses, among which Andes hantavirus (ANDV) is endemic to Chile and Southern Argentina. The disease caused by ANDV produces plasma leakage leading to enhanced vascular permeability and has a high case fatality rate (35%), mainly due to respiratory failure, pulmonary edema and myocardial dysfunction, hypoperfusion and shock. Host
sociodemographic and genetic factors might influence the course and outcome of the disease. Yet, they have not been thoroughly characterized. Aim: To evaluate sociodemographic factors as risk factors in severity of HCPS. Patients and Methods: Study period: 2004-20013, attending in eight collaborative centers, etiological diagnosis
was performed by serology or molecular biology, mild and severe HCPS were compared.139 Chilean patients were analyzed, 64 (46%) with severe disease among which 12 (19 %) died. Results: European ethnicity had 5,1 times higher risk than Amerindian ethnic group to develop a severe HCPS, greater seriousness that was also associated with an urban residence. Conclusion: It was observed that ethnicity and type of residence were significant risk factors for HCPS severity. Hypotheses explaining these findings are discussed.
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Citation
Vial C. Cecilia, Valdivieso R. Francisca, Cuiza V. Analía, Delgado B. Iris, Ribeiro E. Grazielle, Llop R. Elena et al . Factores de riesgo socio-demográficos del síndrome cardiopulmonar por hantavirus. Revista Chilena de Infectología. [Internet]. 2019 Ago [citado 2022 Jul 18] ; 36( 4 ): 428-432. Disponible en: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-10182019000400428&lng=es. http://dx.doi.org/10.4067/S0716-10182019000400428.
Keywords
Susceptibilidad étnica, Infección por hantavirus, Síndrome cardiopulmonar por hantavirus, Hantavirus Andes, Hantavirus