Subclinical Detection of Diabetic Cardiomyopathy with MicroRNAs: Challenges and Perspectives

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dc.contributor.authorLeón, Luis
dc.contributor.authorRani, Sweta
dc.contributor.authorFernández, Mauricio
dc.contributor.authorLarico, Martín
dc.contributor.authorCalligaris, Sebastián
dc.date.accessioned2017-01-04T14:54:35Z
dc.date.available2017-01-04T14:54:35Z
dc.date.issued2016
dc.descriptionCentro de Genética y Genómica
dc.description.abstractThe prevalence of cardiac diabetic diseases has been increased around the world, being the most common cause of death and disability among diabetic patients. In particular, diabetic cardiomyopathy is characterized with a diastolic dysfunction and cardiac remodelling without signs of hypertension and coronary artery diseases. In an early stage, it is an asymptomatic disease; however, clinical studies demonstrate that diabetic myocardia are more vulnerable to injury derived by acute myocardial infarct and are the worst prognosis for rehabilitation. Currently, biochemical and imaging diagnostic methods are unable to detect subclinical manifestation of the disease (prior to diastolic dysfunction). In this review, we elaborately discuss the current scientific evidences to propose circulating microRNAs as promising biomarkers for early detection of diabetic cardiomyopathy and, then, to identify patients at high risk of diabetic cardiomyopathy development. Moreover, here we summarise the research strategies to identify miRNAs as potential biomarkers, present limitations, challenges, and future perspectives.
dc.identifier.citationLeón LE, Rani S, Fernandez M, Larico M, Calligaris SD. Subclinical Detection of Diabetic Cardiomyopathy with MicroRNAs: Challenges and Perspectives. J Diabetes Res. 2016;2016:6143129.
dc.identifier.urihttp://hdl.handle.net/11447/918
dc.identifier.urihttp://dx.doi.org/ 10.1155/2016/6143129
dc.language.isoen_US
dc.publisherHindawi Publishing Corporation
dc.subjectDiabetic cardiomyopathy
dc.subjectMicroRNAs
dc.titleSubclinical Detection of Diabetic Cardiomyopathy with MicroRNAs: Challenges and Perspectives
dc.typeArtículo

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