Role of Astroglial Hemichannels and Pannexons in Memory and Neurodegenerative Diseases

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dc.contributor.authorOrellana, Juan
dc.contributor.authorRetamal, Mauricio
dc.contributor.authorMoraga-Amaro, Rodrigo
dc.contributor.authorStehberg, Jimmy
dc.date.accessioned2017-01-03T19:20:42Z
dc.date.available2017-01-03T19:20:42Z
dc.date.issued2016
dc.descriptionCentro de Fisiología Celular e Integrativa
dc.description.abstractUnder physiological conditions, astroglial hemichannels and pannexons allow the release of gliotransmitters from astrocytes. These gliotransmitters are critical in modulating synaptic transmission, plasticity and memory. However, recent evidence suggests that under pathological conditions, they may be central in the development of various neurodegenerative diseases. Here we review current literature on the role of astroglial hemichannels and pannexons in memory, stress and the development of neurodegenerative diseases, and propose that they are not only crucial for normal brain function, including memory, but also a potential target for the treatment of neurodegenerative diseases.
dc.identifier.citationFrontiers in Integrative Neuroscience
dc.identifier.urihttp://hdl.handle.net/11447/913
dc.identifier.urihttp://dx.doi.org/ 10.3389/fnint.2016.00026
dc.language.isoen_US
dc.publisherLausanne, Switzerland : Frontiers Research Foundation
dc.subjectCx hemichannels
dc.subjectConnexin 43
dc.subjectAstrocytes
dc.subjectConnexin hemichannels
dc.subjectMemory
dc.subjectPannexin
dc.titleRole of Astroglial Hemichannels and Pannexons in Memory and Neurodegenerative Diseases
dc.typeArtículo

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