Influenza vaccination and cardiovascular risk in patients with recent TIA and stroke

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dc.contributor.authorLavallée, Philippa
dc.contributor.authorLabreuche, Julien
dc.contributor.authorFox, Kim
dc.contributor.authorLavados, Pablo
dc.contributor.authorMattle, Heinrich
dc.contributor.authorSteg, Philippe
dc.contributor.authorAmarenco, Pierre
dc.date.accessioned2017-03-14T15:33:05Z
dc.date.available2017-03-14T15:33:05Z
dc.date.issued2014
dc.description.abstractOBJECTIVES: To determine whether current influenza vaccination is associated with reduced risk of major vascular events in patients with recent ischemic stroke or TIA of mainly atherothrombotic origin. METHODS: Data were pooled from 2 prospective cohort studies, the OPTIC Registry (n = 3,635) and the AMISTAD Study (n = 618), and from the randomized PERFORM Trial (n = 19,120), all of which included patients with recent ischemic stroke or TIA. Influenza vaccination status was determined in 23,110 patients. The primary outcome was a composite of nonfatal myocardial infarction, nonfatal stroke, or vascular death up to 2 years. Secondary outcomes were myocardial infarction and stroke separately. RESULTS: Influenza vaccination had no association with the primary outcome in the propensity score-matched cohort (hazard ratio 0.97, 95% confidence interval [CI] 0.85-1.11; p = 0.67) or in the propensity score-adjusted cohort (hazard ratio 1.00, 95% CI 0.89-1.12; p = 0.99). Similarly, the risk of stroke and myocardial infarction did not differ between the vaccinated group and the unvaccinated group; in the matched cohort, the hazard ratio was 1.01 (95% CI 0.88-1.17; p = 0.89) for stroke and 0.84 (95% CI 0.59-1.18; p = 0.30) for myocardial infarction. CONCLUSIONS: Influenza vaccination was not associated with reduced outcome events in patients with recent atherothrombotic ischemic stroke after considering all baseline characteristics (including concomitant medications) associated with influenza vaccination.
dc.format.extent1
dc.identifier.citationNeurology. 2014 May 27;82(21) p:1905-1913
dc.identifier.urihttp://hdl.handle.net/11447/1026
dc.identifier.urihttp://dx.doi.org/10.1212/WNL.0000000000000456
dc.language.isoen_US
dc.publisherAmerican Academy of Neurology
dc.subjectInfluenza Vaccines
dc.subjectCardiovascular Diseases/mortality
dc.subjectTransient/epidemiology
dc.subjectIschemic Attack
dc.subjectRisk Factors
dc.subjectStroke/epidemiology
dc.subjectVaccination
dc.titleInfluenza vaccination and cardiovascular risk in patients with recent TIA and stroke
dc.typeArtículo

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