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Multipotent mesenchymal stromal cells: A promising strategy to manage alcoholic liver disease

Show simple item record Ezquer, Fernando Bruna, Flavia Calligaris, Sebastián Conget, Paulette Ezquer, Marcelo 2017-01-04T17:33:32Z 2017-01-04T17:33:32Z 2016
dc.identifier.citation World Journal of Gastroenterology, January 2016, vol.22,n°1,p.24-36 es_CL
dc.identifier.uri 10.3748/WJG.v22.i1.24 es_CL
dc.description Centro de Medicina Regenerativa es_CL
dc.description.abstract Chronic alcohol consumption is a major cause of liver disease. The term alcoholic liver disease (ALD) refers to a spectrum of mild to severe disorders including steatosis, steatohepatitis, cirrhosis, and hepatocellular carcinoma. With limited therapeutic options, stem cell therapy offers significant potential for these patients. In this article, we review the pathophysiologic features of ALD and the therapeutic mechanisms of multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), based on their potential to differentiate into hepatocytes, their immunomodulatory properties, their potential to promote residual hepatocyte regeneration, and their capacity to inhibit hepatic stellate cells. The perfect match between ALD pathogenesis and MSC therapeutic mechanisms, together with encouraging, available preclinical data, allow us to support the notion that MSC transplantation is a promising therapeutic strategy to manage ALD onset and progression. es_CL
dc.language.iso en_US es_CL
dc.publisher WJG Press es_CL
dc.subject Alcoholic liver disease es_CL
dc.subject Alcoholic steatohepatitis es_CL
dc.subject Cellular therapy es_CL
dc.subject Hepatic function recovery es_CL
dc.subject Mesenchymal stem cells es_CL
dc.title Multipotent mesenchymal stromal cells: A promising strategy to manage alcoholic liver disease es_CL
dc.type Artículo es_CL

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