Efficacy of combined radiotherapy and chemotherapy versus radiotherapy for oral squamous cell carcinoma
Date
2015
Type:
Article
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Abstract
Introduction: in the last decade, with all the advanced medical research in the treatments for cancer, there is a constant debate for the best possible treatment for oral squamous cell carcinomas. Radiotherapy with surgery has they compared with the addition of chemotherapy for control of the disease or survival of the patient. Objective: to compare the effectiveness of radiotherapy with combined chemotherapy and radiotherapy for the control of oral squamous cell carcinomas. Methods: it was a systematic review with metaanalysis. Randomized trials in all phases were search with specific inclusion criteria through electronic database, hand searching and contacting experts in the field. After exclusion, criteria and the use of critical review checklist, three trials they selected for analysis. Three randomized trials representing 508 patients they identified. Some trials they analyzed in Review manager software 5.0®. The fix effect model they chosen for the statistical analysis, assuming that any observed variation in the score was an error of the specific article, with a confidence of 95 % (CI 1.13–2.77). The I2 presents percent of heterogeneity of 0 %, indicating that there is no clinically significant change in the results of the studies included. Result: evidenced the significance of 0.44 (higher than 0.05) in the chi square test indicating that the results are homogeneous or clinically similar. The Forest plot is located in the experimental group (chemotherapy and radiotherapy), establishing the clinical recommendation of use. Conclusion: the usage of chemotherapy treatment in combination of radiotherapy regimen they recommended as for its promising results. Not also, the overall survival has improved, survival and distant metastasis free rates improve.
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Citation
Arévalo, Jaime & Mella, Patricio. (2015). Efficacy of combined radiotherapy and chemotherapy versus radiotherapy for oral squamous cell carcinoma. Revista Cubana de Estomatología. 52(4):52-
Keywords
Carcinoma, Squamous-cell, Radiotherapy, Chemotherapy, Cancer oral