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Lateral prefrontal activity as a compensatory strategy for deficits of cortical processing in Attention Deficit Hyperactivity Disorder

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dc.contributor.author Zamorano, Francisco
dc.contributor.author Aboitiz, Francisco
dc.contributor.author Carrasco, Ximena
dc.contributor.author López, Vladimir
dc.contributor.author Hurtado, José M.
dc.contributor.author Stecher, Ximena
dc.contributor.author Larrain, Josefina
dc.contributor.author Kausel, Leonie
dc.contributor.author Billeke, Pablo
dc.date.accessioned 2018-02-23T15:50:16Z
dc.date.available 2018-02-23T15:50:16Z
dc.date.issued 2017
dc.identifier.citation Scientific Reports, Volumen: 7 Número de artículo: 7181 es_CL
dc.identifier.uri http://dx.doi.org/10.1038/s41598-017-07681-z es_CL
dc.identifier.uri http://hdl.handle.net/11447/1997
dc.description.abstract Attention Deficit Hyperactivity Disorder (ADHD) is the most common neuropsychiatric disorder in childhood and is characterized by a delay of cortical maturation in frontal regions. In order to investigate interference control, which is a key function of frontal areas, a functional MRI study was conducted on 17 ADHD boys and 17 typically developing (TD) boys, while solving the multi source interference task (MSIT). This task consists of two conditions, a "congruent condition" and an "incongruent condition". The latter requires to inhibit information that interferes with task-relevant stimuli. Behavioral results showed that ADHD subjects committed more errors than TD children. In addition, TD children presented a larger MSIT effect -a greater difference in reaction times between the incongruent and the congruent conditions- than ADHD children. Associated to the MSIT effect, neuroimaging results showed a significant enhancement in the activation of the right lateral prefrontal cortex (rlPFC) in ADHD than in TD subjects. Finally, ADHD subjects presented greater functional connectivity between rlPFC and bilateral orbitofrontal cortex than the TD group. This difference in connectivity correlated with worse performance in both groups. Our results could reflect a compensatory strategy of ADHD children resulting from their effort to maintain an adequate performance during MSIT. es_CL
dc.language.iso en_US es_CL
dc.subject ADHD es_CL
dc.subject Bipolar Disorder es_CL
dc.subject Executive functions es_CL
dc.subject Response-inhibition es_CL
dc.subject Psychiatric-disorders es_CL
dc.subject Behavioral-inhibition es_CL
dc.subject Cognitive control es_CL
dc.subject Orbitofrontal cortex es_CL
dc.subject Hyperactivity Disorder es_CL
dc.subject Deficit es_CL
dc.subject Multisource interference task es_CL
dc.title Lateral prefrontal activity as a compensatory strategy for deficits of cortical processing in Attention Deficit Hyperactivity Disorder es_CL
dc.type Artículo es_CL


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