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The boundaries of mild chronic obstructive pulmonary disease (COPD): Design of the searching clinical COPD onset (SOON) study

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dc.contributor.author Labarca, Gonzalo
dc.contributor.author Bustamante, Andrea
dc.contributor.author Valdivia, Gonzalo
dc.contributor.author Diaz, Rodrigo
dc.contributor.author Huete, Alvaro
dc.contributor.author Mac Nab, Paul
dc.contributor.author Mendoza, Laura
dc.contributor.author Leppe, Jaime
dc.contributor.author Lisboa, Carmen
dc.contributor.author Saldias, Fernando
dc.contributor.author Diaz, Orlando
dc.date.accessioned 2018-01-10T13:32:01Z
dc.date.available 2018-01-10T13:32:01Z
dc.date.issued 2017
dc.identifier.citation BMJ Open 2017;7:e015731 es_CL
dc.identifier.uri http://dx.doi.org/10.1136/bmjopen-2016-015731 es_CL
dc.identifier.uri http://hdl.handle.net/11447/1877
dc.description.abstract INTRODUCTION: Clinical onset of chronic obstructive pulmonary disease (COPD) is the point at which the disease is first identifiable by physicians. It is a poorly defined stage which seems to include both mild spirometric and non-spirometric disease, and could be described as early grade COPD, for practical purposes. While dyspnoea; chronic bronchitis and CT imaging evidence of emphysema and airway disease may be present very early, the lone significance of dyspnoea, the most relevant symptom in COPD in identifying these individuals, has been scarcely assessed.The Searching Clinical COPD Onset (SOON) Study was designed primarily to detect clinical, physiological and structural differences between dyspnoeic and non-dyspnoeic individuals with early grade COPD. It is hypothesised that presence of dyspnoea in early disease may identify a subtype of individuals with reduced exercise capacity, notwithstanding of their spirometry results. In addition, dyspnoeic individuals will share worse quality of life, lower physical activity, greater lung hyperinflation greater emphysema and airway thickness and reduced peripheral muscle mass than their non-dyspnoeic counterpart. METHODS AND ANALYSIS: SOON is a monocentric study, with a cross sectional design aimed at obtaining representative samples of current or ex-smoker-adults aged ≥45 and ≤80 years. Two hundred and forty participants will be enrolled into four strata, according to normal spirometry or mild spirometric obstruction and presence or not of dyspnoea modified Medical Research Council score ≥1. The primary outcome will be the difference between dyspnoeic and non-dyspnoeic individuals on the 6-min walk test performance, regardless of their spirometry results. To account for the confounding effect of heart failure on dyspnoea, stress echocardiography will be also performed. Secondary outcomes will include clinical (quality of life, physical activity), physiological (exercise testing) and structural characteristics (emphysema, airway disease and peripheral muscle mass by CT imaging). ETHICS AND DISSEMINATION: The Institutional Ethics Committee from Pontificia Universidad Católica de Chile has approved the study protocol and signed informed consent will be obtained from all participants. The findings of the trial will be disseminated through relevant peer-reviewed journals and international conference presentations. es_CL
dc.format.extent 8 es_CL
dc.language.iso en_US es_CL
dc.publisher BMJ Publishing Group es_CL
dc.subject adult thoracic medicine es_CL
dc.subject chronic airways disease es_CL
dc.subject emphysema es_CL
dc.subject general medicine es_CL
dc.subject thoracic medicine es_CL
dc.title The boundaries of mild chronic obstructive pulmonary disease (COPD): Design of the searching clinical COPD onset (SOON) study es_CL
dc.type Artículo es_CL


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