Predictors of new-onset depressive disorders – Results from the longitudinal Finnish Health 2011 Study
Date
2016
Type:
Artículo
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10
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Publisher
Elsevier
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Abstract
Depressive disorders are among the most pressing public health challenges worldwide. Yet, not
enough is known about their long-term outcomes. This study examines the course and predictors
of different outcomes of depressive disorders in an eleven-year follow-up of a general population
sample.
METHODS: In a nationally representative sample of Finns aged 30 and over (BRIF8901), major
depressive disorder (MDD) and dysthymia were diagnosed with the Composite International
Diagnostic Interview (M-CIDI) in 2000. The participants were followed up in 2011 (n=5733).
Outcome measures were diagnostic status, mortality, depressive symptoms and health-related
quality of life. Multiple imputation (MI) was used to account for nonresponse.
RESULTS: At follow-up, 33.8% of persons with baseline MDD and 42.6% with baseline dysthymia
received a diagnosis of depressive, anxiety or alcohol use disorder. Baseline severity of disorder,
measured by the Beck Depression Inventory, predicted both persistence of depressive disorder and
increased mortality risk. In addition, being never-married, separated or widowed predicted
persistence of depressive disorders, whereas somatic and psychiatric comorbidity, childhood
adversities and lower social capital did not. Those who received no psychiatric diagnosis at followup
still had residual symptoms and lower quality of life.
LIMITATIONS: We only had one follow-up point at eleven years, and did not collect information on
the subjects' health during the follow-up period.
CONCLUSIONS: Depressive disorders in the general population are associated with multiple
negative outcomes. Severity of index episode is the strongest predictor of negative outcomes. More
emphasis should be placed on addressing the long-term consequences of depression.
Description
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Citation
Markkula N, Marola N, Nieminen T, Koskinen S, Saarni SI, Härkänen T, Suvisaari J. Predictors of new-onset depressive disorders - Results from the longitudinal Finnish Health 2011 Study. J Affect Disord. 2017 Jan 15;208:255-264. doi: 10.1016/j.jad.2016.08.051.
Keywords
Depressive disorders, Epidemiology, Risk factors, Major depressive disorder, Dysthymia, General population