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Head position and cerebral blood flow in acute ischemic stroke patients: protocol for the pilot phase, cluster randomized, Head Position in Acute Ischemic Stroke Trial (HeadPoST pilot)

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dc.contributor.author Brunser, Alejandro
dc.contributor.author Muñoz-Venturelli, Paula
dc.contributor.author Lavados, Pablo
dc.contributor.author Gaete, Javier
dc.contributor.author Martins, Sheila
dc.contributor.author Arima, Hisatomi
dc.contributor.author Anderson, Craig
dc.contributor.author Olavarría, Verónica
dc.date.accessioned 2017-05-15T13:56:27Z
dc.date.available 2017-05-15T13:56:27Z
dc.date.issued 2016
dc.identifier.citation Int J Stroke. 2016 Feb;11(2):253-9 es_CL
dc.identifier.uri http://dx.doi.org/10.1177/1747493015620808 es_CL
dc.identifier.uri http://hdl.handle.net/11447/1242
dc.description.abstract RATIONALE: Few proven interventions exist for acute ischemic stroke (AIS), and most are expensive and restricted in applicability. Lying flat 'head down' positioning of AIS patients has been shown to increase by as much as 20%, mean cerebral blood flow velocities (CBFV) measured by transcranial Doppler (TCD) but whether this translates into clinical improvement is uncertain. AIM: To determine if the lying flat position increases mean CBFV in the affected territory as compared to the sitting up position in AIS patients. METHODS AND DESIGN: Head Position in Acute Ischemic Stroke Trial (HeadPoST pilot) is a cluster randomized (clusters being months), assessor-blinded end-point, phase IIb trial, where consecutive adults with anterior circulation AIS within 12 h of symptom onset are positioned to a randomized position for 48 h with TCD performed serially. STUDY OUTCOMES: Primary outcome is mean CBFV on TCD at 1 and 24 h after positioning. Secondary outcomes include: serious adverse events, neurological impairment at seven days, and death and disability at 90 days. SAMPLE SIZE ESTIMATES: Assuming an increase of 8.3 (SD 11.4) cm/s in average of mean CBFV when tilted from 30° to 0°, 46 clusters are required (92 patients in total) to detect a 20% increase of mean CBFV with 90% power and 5% level of significance. CONCLUSION: HeadPoST pilot is a cluster randomized multicenter clinical trial investigating the effect of head positioning on mean CBFV in anterior circulation AIS. es_CL
dc.format.extent 7 es_CL
dc.language.iso en_US es_CL
dc.publisher Sage Publications es_CL
dc.subject Ischemic stroke es_CL
dc.subject Blood flow velocity es_CL
dc.subject Head position es_CL
dc.subject Middle cerebral artery es_CL
dc.subject Pilot trial es_CL
dc.subject Transcranial Doppler es_CL
dc.title Head position and cerebral blood flow in acute ischemic stroke patients: protocol for the pilot phase, cluster randomized, Head Position in Acute Ischemic Stroke Trial (HeadPoST pilot) es_CL
dc.type Artículo es_CL


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