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Profile of idiosyncratic drug induced liver injury in Latin America. An analysis of published reports

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dc.contributor.author Sánchez, Adriana
dc.contributor.author di Pace, María
dc.contributor.author Brahm, Javier
dc.contributor.author Zapata, Rodrigo
dc.contributor.author Chirino, Ruby
dc.contributor.author Dávalos, Milagros
dc.contributor.author Méndez-Sánchez, Nahum
dc.contributor.author Arrese, Marco
dc.contributor.author Schinoni, María
dc.contributor.author Lucena, Isabel
dc.contributor.author Andrade, Raúl
dc.date.accessioned 2017-03-23T14:46:30Z
dc.date.available 2017-03-23T14:46:30Z
dc.date.issued 2014
dc.identifier.citation Ann Hepatol. 2014 Mar-Apr;13(2) p:231-239 es_CL
dc.identifier.uri http://hdl.handle.net/11447/1052
dc.description.abstract NTRODUCTION: Drug-induced liver injury (DILI) remains a major problem for drug development and represents a challenging diagnosis for clinicians. The absence of specific biomarkers for diagnosing DILI precludes the availability of reliable data on the epidemiology of the disease. In this study we aimed to describe the features of idiosyncratic hepatotoxicity reports in Latin American countries. MATERIAL AND METHODS: A literature search was performed using the online version of MEDLINE, EMBASE, Scopus, Google Scholar and specific data bases from Latin America (LA) (Scielo, Lilacs) to identify any case report or case series of published DILI from 1996 to 2012. From 1996 to 2012, a total of 176 patients with DILI were published in LA, involving 53 suspicious drugs. The median age in the adult population of these patients was 55 years (17-82) with prevalence of women (67%). Among main therapeutic classes, the rank order was led by non-steroidal anti-inflammatory (61 cases) and systemic antibacterial drugs (37 cases). Nimesulide was the individual drug responsible for the highest number of cases (53), followed by cyproterone acetate (18), nitrofurantoin (17), antituberculous drugs (13) and flutamide (12). Thirty two percent of published cases evolved to acute liver failure (ALF), and half of the subjects required liver transplantation or eventually died. CONCLUSIONS: This study represents the first structured attempt to assess the spectrum of DILI profile in LA. The establishment of a Latin American registry to collect prospective DILI cases using a standardized protocol will advance our knowledge about idiosyncratic DILI in this region. es_CL
dc.format.extent 1 es_CL
dc.language.iso en_US es_CL
dc.publisher Ediciones Medicina y Cultura es_CL
dc.subject Drug-induced acute liver failure es_CL
dc.subject Liver toxicity es_CL
dc.subject DILI es_CL
dc.subject Fulminant liver failure es_CL
dc.subject Hepatotoxicity es_CL
dc.title Profile of idiosyncratic drug induced liver injury in Latin America. An analysis of published reports es_CL
dc.type Artículo es_CL


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