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Utility of bronchodilator response for asthma diagnosis in Latino preschoolers

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dc.contributor.author Linares Passerini
dc.contributor.author Meyer Peirano
dc.contributor.author Contreras Estay
dc.contributor.author Delgado Becerra
dc.contributor.author Castro-Rodriguez
dc.date.accessioned 2017-03-03T20:02:58Z
dc.date.available 2017-03-03T20:02:58Z
dc.date.issued 2014
dc.identifier.citation Allergologia et Immunopathologia Volume 42, Issue 6, Nov–Dec 2014, p.553–559 es_CL
dc.identifier.uri http://dx.doi.org/10.1016/j.aller.2014.02.004 es_CL
dc.identifier.uri http://hdl.handle.net/11447/1001
dc.description Centro de Epidemiología y Políticas de Salud es_CL
dc.description.abstract Background Asthma diagnosis in preschoolers is mostly based on clinical evidence, but a bronchodilator response could be used to help confirm the diagnosis. The objective of this study is to evaluate the utility of bronchodilator response for asthma diagnosis in preschoolers by using spirometry standardised for this specific age group. Methods A standardised spirometry was performed before and after 200 mcg of salbutamol in 64 asthmatics and 32 healthy control preschoolers in a case-control design study. Results The mean age of the population was 4.1 years (3–5.9 years) and 60% were females. Almost 95% of asthmatics and controls could perform an acceptable spirometry, but more asthmatics than controls reached forced expiratory volume in one second (FEV1) (57% vs. 23%, p = 0.033), independent of age. Basal flows and FEV1 were significantly lower in asthmatics than in controls, but no difference was found between groups in forced vital capacity (FVC) and FEV in 0.5 s (FEV0.5). Using receiver operating characteristic (ROC) curves, the variable with higher power to discriminate asthmatics from healthy controls was a bronchodilator response (% of change from basal above the coefficient of repeatability) of 25% in forced expiratory flow between 25% and 75% (FEF25–75) with 41% sensitivity, 80% specificity. The higher positive likelihood ratio for asthma equalled three for a bronchodilator response of 11% in FEV0.5 (sensitivity 30%, specificity 90%). Conclusions In this sample of Chilean preschoolers, spirometry had a very high performance and bronchodilator response was very specific but had low sensitivity to confirm asthma diagnosis. es_CL
dc.format.extent 1 es_CL
dc.language.iso en_US es_CL
dc.publisher Elsevier es_CL
dc.subject Asthma es_CL
dc.subject Bronchodilator response es_CL
dc.subject Diagnosis es_CL
dc.subject Preschoolers es_CL
dc.subject Spirometry es_CL
dc.title Utility of bronchodilator response for asthma diagnosis in Latino preschoolers es_CL
dc.type Artículo es_CL


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