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EV-miRNA-Mediated Intercellular Communication in the Breast Tumor Microenvironment

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dc.contributor.authorSepúlveda, Francisca
dc.contributor.authorMayorga, Cristina
dc.contributor.authorGuzmán, Kevin
dc.contributor.authorDurán, Eduardo
dc.contributor.authorLobos, Lorena
dc.date.accessioned2024-04-03T19:08:38Z
dc.date.available2024-04-03T19:08:38Z
dc.date.issued2023
dc.description.abstractCancer research has prioritized the study of the tumor microenvironment (TME) as a crucial area of investigation. Understanding the communication between tumor cells and the various cell types within the TME has become a focal point. Bidirectional communication processes between these cells support cellular transformation, as well as the survival, invasion, and metastatic dissemination of tumor cells. Extracellular vesicles are lipid bilayer structures secreted by cells that emerge as important mediators of this cell-to-cell communication. EVs transfer their molecular cargo, including proteins and nucleic acids, and particularly microRNAs, which play critical roles in intercellular communication. Tumor-derived EVs, for example, can promote angiogenesis and enhance endothelial permeability by delivering specific miRNAs. Moreover, adipocytes, a significant component of the breast stroma, exhibit high EV secretory activity, which can then modulate metabolic processes, promoting the growth, proliferation, and migration of tumor cells. Comprehensive studies investigating the involvement of EVs and their miRNA cargo in the TME, as well as their underlying mechanisms driving tumoral capacities, are necessary for a deeper understanding of these complex interactions. Such knowledge holds promise for the development of novel diagnostic and therapeutic strategies in cancer treatment.
dc.description.versionPublicada
dc.identifier.citationSepúlveda, F.; Mayorga-Lobos, C.; Guzmán, K.; Durán-Jara, E.; Lobos-González, L. EV-miRNA-Mediated Intercellular Communication in the Breast Tumor Microenvironment. Int. J. Mol. Sci. 2023, 24, 13085. https://doi.org/ 10.3390/ijms241713085
dc.identifier.doihttps://doi.org/10.3390/ijms241713085
dc.identifier.urihttps://hdl.handle.net/11447/8590
dc.language.isoen
dc.subjectExtracellular vesicles
dc.subjectSmall EVs
dc.subjectCancer progression
dc.subjectmiRNAs
dc.subjectTumor progression
dc.subjectMetastasis
dc.titleEV-miRNA-Mediated Intercellular Communication in the Breast Tumor Microenvironment
dc.typeArticle
dcterms.accessRightsAcceso Abierto
dcterms.sourceInternational journal of molecular sciences
dspace.entity.typePublication

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