Chan, EdwardAnderson, CraigWang, XiaArima, HisatomiSaxena, AnubhavMoullaali, TomDelcourt, CandiceWu, GuojunWang, JinchaoChen, GuofangLavados, PabloStampf, ChristianRobinson, ThompsonChalmers, John2017-08-162017-08-162016Chan E, Anderson C, S, Wang X, Arima H, Saxena A, Moullaali T, J, Delcourt C, Wu G, Wang J, Chen G, Lavados P, M, Stapf C, Robinson T, Chalmers J: Early Blood Pressure Lowering Does Not Reduce Growth of Intraventricular Hemorrhage following Acute Intracerebral Hemorrhage: Results of the INTERACT Studies. Cerebrovasc Dis Extra 2016;6:71-75.http://hdl.handle.net/11447/1583http://dx.doi.org/10.1159/000448897Background Intraventricular hemorrhage (IVH) extension is common following acute intracerebral hemorrhage (ICH) and is associated with poor prognosis. Aim To determine whether intensive blood pressure (BP)-lowering therapy reduces IVH growth. Methods Pooled analyses of the Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trials (INTERACT1 and INTERACT2) computed tomography (CT) substudies; multicenter, open, controlled, randomized trials of patients with acute spontaneous ICH and elevated systolic BP, randomly assigned to intensive (<140 mm Hg) or guideline-based (<180 mm Hg) BP management. Participants had blinded central analyses of baseline and 24-hour CT. Association of BP lowering to IVH growth was assessed in analysis of covariance. Results There was no significant difference in adjusted mean IVH growth following intensive (n = 228) compared to guideline-recommended (n = 228) BP treatment (1.6 versus 2.2 ml, respectively; p = 0.56). Adjusted mean IVH growth was nonsignificantly greater in patients with a mean achieved systolic BP ≥160 mm Hg over 24 h (3.94 ml; p trend = 0.26). Conclusions Early intensive BP-lowering treatment had no clear effect on IVH in acute ICH.5en-USStrokeIntracerebral hemorrhageIntraventricular hemorrhageHypertensionIntensive blood pressure loweringArtículo