Borre, EthanAyer, AustinDer, CarolinaIbekwe, TitusEmmett, SusanDixit, SiddharthShahid, MinahilOlusanya, BolajokoGarg, SuneelaJohri, MohiniSaunders, JamesTucci, DebaraWilson, BlakeOgbuoji, OsonduSanders, Gillian2023-04-252023-04-252022Borre ED, Ayer A, Der C, Ibekwe T, Emmett SD, Dixit S, Shahid M, Olusanya B, Garg S, Johri M, Saunders JE, Tucci DL, Wilson BS, Ogbuoji O, Sanders Schmidler GD. Validation of the Decision model of the Burden of Hearing loss Across the Lifespan (DeciBHAL) in Chile, India, and Nigeria. EClinicalMedicine. 2022 Jun 17;50:101502. doi: 10.1016/j.eclinm.2022.101502https://repositorio.udd.cl/handle/11447/7375Background: There is no published decision model for informing hearing health care resource allocation across the lifespan in low- and middle-income countries. We sought to validate the Decision model of the Burden of Hearing loss Across the Lifespan International (DeciBHAL-I) in Chile, India, and Nigeria. Methods: DeciBHAL-I simulates bilateral sensorineural hearing loss (SNHL) and conductive hearing loss (CHL) acquisition, SNHL progression, and hearing loss treatment. To inform model inputs, we identified setting-specific estimates including SNHL prevalence from the Global Burden of Disease (GBD) studies, acute otitis media (AOM) incidence and prevalence of otitis-media related CHL from a systematic review, and setting-specific pediatric and adult hearing aid use prevalence. We considered a coefficient of variance root mean square error (CV-RMSE) of ≤15% to indicate good model fit. Findings: The model-estimated prevalence of bilateral SNHL closely matched GBD estimates, (CV-RMSEs: 3.2-7.4%). Age-specific AOM incidences from DeciBHAL-I also achieved good fit (CV-RMSEs=5.0-7.5%). Model-projected chronic suppurative otitis media prevalence (1.5% in Chile, 4.9% in India, and 3.4% in Nigeria) was consistent with setting-specific estimates, and the incidence of otitis media-related CHL was calibrated to attain adequate model fit. DeciBHAL-projected adult hearing aid use in Chile (3.2-19.7% ages 65-85 years) was within the 95% confidence intervals of published estimates. Adult hearing aid prevalence from the model in India was 1.4-2.3%, and 1.1-1.3% in Nigeria, consistent with literature-based and expert estimates. Interpretation: DeciBHAL-I reasonably simulates hearing loss natural history, detection, and treatment in Chile, India, and Nigeria. Future cost-effectiveness analyses might use DeciBHAL-I to inform global hearing health policy.enDecision modelingGlobal health policyHearing lossArticle