Santos, MaríaHerrera O., Patricio2021-08-202021-08-202020Revista Chilena de Pediatría, 2020, vol.91(2):246-250https://dx.doi.org/10.32641/rchped.v91i2.1223http://hdl.handle.net/11447/4416Objective: To describe two cases of mediastinal lipoblastoma, an infrequent and little-known pathology, which is extremely rare in the mediastinum, with no cases reported in our country. Clinical Cases: Two case reports. Both patients were boys younger than three years, in which a mediastinal mass was found incidentally on a chest x-ray. The study was complemented with a CT scan and with a thoracoscopic biopsy in one of the cases. Complete resection of the tumor was achieved in both patients through thoracotomy. One of the patients presented Claude Bernard Horner syndrome as a complication from surgery, which resolved spontaneously after two years and the second case had no complications. Conclusion: Mediastinal lipoblastoma is a very rare pathology. Descriptions found in existing literature are similar to the cases presented in this article. We can conclude that mediastinal lipoblastomas in pediatrics present a very similar pattern and presentation, having a good prognosis if complete resection is achieved. Also, it is essential to distinguish it from its differential diagnoses in order to rule out malignancyenLipoblastomaChildrenMediastinumNeoplasmsArticle